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Tytuł:
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Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity.
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Autorzy:
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de Freitas Brito A; School of Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil.; Post-Graduation Program in Physical Education UPE/UFPB, Brazil.
Silva AS; Post-Graduation Program in Physical Education UPE/UFPB, Brazil.; Physical Education Department, Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.; Laboratory of Studies of Physical Training Applied to the Performance and the Health, Health Sciences Center/Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
de Souza AA; Federal University of Tocantins, Tocantinópolis, Tocantins, Brazil.
Ferreira PB; Postgraduate Program in Natural and Synthetic Products Bioactive/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
de Souza ILL; Department of Biological Sciences and Health, State University of Roraima, Boa Vista, Roraima, Brazil.
da Cunha Araujo LC; Department of Biophysics and Physiology, University of Sao Paulo, Institute of Biomedical Sciences, Sao Paulo, Sao Paulo, Brazil.
da Silva Félix G; Post-Graduation Program in Physical Education UPE/UFPB, Brazil.; Laboratory of Studies of Physical Training Applied to the Performance and the Health, Health Sciences Center/Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
de Souza Sampaio R; Postgraduate Program in Natural and Synthetic Products Bioactive/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
da Conceição Correia Silva M; Postgraduate Program in Natural and Synthetic Products Bioactive/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Tavares RL; Postgraduate Program in Nutrition Science/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
de Andrade Pereira R; Post-Graduation Program in Physical Education UPE/UFPB, Brazil.; Laboratory of Studies of Physical Training Applied to the Performance and the Health, Health Sciences Center/Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Neto MM; Postgraduate Program in Nutrition Science/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Silva BA; Postgraduate Program in Natural and Synthetic Products Bioactive/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.; Pharmaceutical Sciences Department/Health Sciences Center, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
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Źródło:
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Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2019 Oct 24; Vol. 2019, pp. 7838149. Date of Electronic Publication: 2019 Oct 24 (Print Publication: 2019).
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
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MeSH Terms:
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Antioxidants/*metabolism
Aorta/*drug effects
Nitric Oxide/*metabolism
Spirulina/*chemistry
Animals ; Dietary Supplements ; Rats
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References:
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Pharmacol Rev. 2003 Dec;55(4):597-606. (PMID: 14657418)
Hypertens Res. 2012 Nov;35(11):1039-47. (PMID: 22972557)
Curr Pharm Des. 2013;19(13):2382-9. (PMID: 23173587)
Ann Hepatol. 2014 Mar-Apr;13(2):273-83. (PMID: 24552870)
Life Sci. 2002 Mar 8;70(16):1841-8. (PMID: 12005170)
Curr Pharm Biotechnol. 2008 Oct;9(5):400-5. (PMID: 18855693)
J Med Food. 2009 Feb;12(1):15-20. (PMID: 19298191)
J Nanosci Nanotechnol. 2016 Jan;16(1):81-91. (PMID: 27398435)
J Med Food. 2013 Feb;16(2):103-11. (PMID: 23402636)
Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R110-20. (PMID: 23115122)
Life Sci. 2003 Dec 19;74(5):603-12. (PMID: 14623031)
Food Chem. 2013 Sep 1;140(1-2):321-31. (PMID: 23578649)
Pflugers Arch. 2010 May;459(6):995-1004. (PMID: 20127126)
Hypertension. 2019 Feb;73(2):449-457. (PMID: 30595120)
Science. 1981 Apr 3;212(4490):56-8. (PMID: 6451927)
Anal Biochem. 1979 Jun;95(2):351-8. (PMID: 36810)
Asian Pac J Trop Biomed. 2011 Jan;1(1):12-4. (PMID: 23569717)
J Med Food. 2007 Dec;10(4):566-70. (PMID: 18158824)
Eur Rev Med Pharmacol Sci. 2016;20(1):150-6. (PMID: 26813468)
J Med Food. 2001 Winter;4(4):193-199. (PMID: 12639401)
Arch Med Res. 2006 Jan;37(1):50-7. (PMID: 16314186)
Nutr Res. 2013 May;33(5):397-405. (PMID: 23684441)
Colloids Surf B Biointerfaces. 2013 Mar 1;103:283-7. (PMID: 23202242)
Life Sci. 2013 Oct 10;93(15):479-86. (PMID: 23994664)
Mediators Inflamm. 2002 Apr;11(2):81-5. (PMID: 12061428)
J Ethnopharmacol. 2001 Apr;75(1):37-44. (PMID: 11282441)
Phytomedicine. 2004 Sep;11(6):490-7. (PMID: 15500259)
Nature. 1980 Nov 27;288(5789):373-6. (PMID: 6253831)
Am J Physiol. 1970 Dec;219(6):1698-705. (PMID: 4320911)
Exp Parasitol. 2012 Oct;132(2):166-70. (PMID: 22771866)
Biomed Res Int. 2013;2013:742859. (PMID: 24063013)
Hypertens Res. 2011 Apr;34(4):431-40. (PMID: 21228777)
J Sci Food Agric. 2014 Feb;94(3):432-7. (PMID: 23754631)
J Agric Food Chem. 2010 Jun 23;58(12):7166-71. (PMID: 20509691)
Zhongguo Zhong Yao Za Zhi. 2005 Feb;30(3):211-5. (PMID: 15719643)
Guang Pu Xue Yu Guang Pu Fen Xi. 2012 Mar;32(3):749-54. (PMID: 22582646)
Microbiol Rev. 1983 Dec;47(4):551-78. (PMID: 6420655)
J Nutr. 2005 Oct;135(10):2425-30. (PMID: 16177207)
Br J Pharmacol. 1990 Nov;101(3):746-52. (PMID: 1706208)
J Complement Integr Med. 2012 Aug 10;9:Article 17. (PMID: 22944720)
Crit Rev Food Sci Nutr. 2011 Aug;51(7):593-604. (PMID: 21793723)
Biochem Biophys Res Commun. 2000 Aug 18;275(1):20-5. (PMID: 10944434)
J Agric Food Chem. 2011 Jan 26;59(2):559-63. (PMID: 21182294)
Evid Based Complement Alternat Med. 2014;2014:525340. (PMID: 24872833)
Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):52-8. (PMID: 18277186)
Planta Med. 2002 Jun;68(6):505-9. (PMID: 12094292)
J Nutr Sci Vitaminol (Tokyo). 2011;57(2):186-91. (PMID: 21697639)
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Substance Nomenclature:
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0 (Antioxidants)
31C4KY9ESH (Nitric Oxide)
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Entry Date(s):
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Date Created: 20191128 Date Completed: 20200410 Latest Revision: 20200410
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Update Code:
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20240104
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PubMed Central ID:
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PMC6854921
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DOI:
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10.1155/2019/7838149
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PMID:
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31772708
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The possible mechanism is involved in the effects of Spirulina platensis on vascular reactivity. Animals were divided into sedentary group (SG) and sedentary groups supplemented with S. platensis at doses of 50 (SG50), 150 (SG150), and 500 mg/kg (SG500). To evaluate reactivity, cumulative concentration-response curves were constructed for phenylephrine and acetylcholine. To evaluate the involvement of the nitric oxide (NO) pathway, aorta tissue was preincubated with L-NAME and a new curve was then obtained for phenylephrine. Biochemical analyses were performed to evaluate nitrite levels, lipid peroxidation, and antioxidant activity. To contractile reactivity, only SG500 (pD 2 = 5.6 ± 0.04 vs. 6.1 ± 0.06, 6.2 ± 0.02, and 6.2 ± 0.04) showed reduction in phenylephrine contractile potency. L-NAME caused a higher contractile response to phenylephrine in SG150 and SG500. To relaxation, curves for SG150 (pD 2 = 7.0 ± 0.08 vs. 6.4 ± 0.06) and SG500 (pD 2 = 7.3 ± 0.02 vs. 6.4 ± 0.06) were shifted to the left, more so in SG500. Nitrite was increased in SG150 and SG500. Lipid peroxidation was reduced, and oxidation inhibition was increased in all supplemented groups, indicating enhanced antioxidant activity. Chronic supplementation with S. platensis (150/500 mg/kg) caused a decrease in contractile response and increase in relaxation and nitrite levels, indicating greater NO production, due to decreased oxidative stress and increased antioxidant activity.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2019 Aline de Freitas Brito et al.)
