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Tytuł:
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A Dilute and Shoot LC-MS/MS Method for Antipsychotics in Urine.
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Autorzy:
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Feng S; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.
Enders JR; Molecular Education, Technology and Research Innovation Center (METRIC), Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27695.
Cummings OT; Insource Diagnostics, 231 West Chestnut Ave., Monrovia, CA 91016, USA.
Strickland EC; Research and Development, Ameritox, LLC, 486 Gallimore Dairy Rd, Greensboro, NC 27409, USA.
McIntire T; Veterans Administration, 1 VA Center, Augusta, ME 04330, USA.
McIntire G; Research and Development, Premier Biotech, 723 Kasota Ave SE, Minneapolis, MN 55414, USA.
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Źródło:
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Journal of analytical toxicology [J Anal Toxicol] 2020 May 18; Vol. 44 (4), pp. 331-338.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2012- : Oxford : Oxford University Press
Original Publication: 1977-<2011>: Niles, Ill., Preston Publications.
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MeSH Terms:
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Antipsychotic Agents/*urine
Aripiprazole ; Chromatography, Liquid ; Drug Monitoring ; Humans ; Limit of Detection ; Quinolones ; Tandem Mass Spectrometry ; Thiophenes
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Substance Nomenclature:
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0 (Antipsychotic Agents)
0 (Quinolones)
0 (Thiophenes)
2J3YBM1K8C (brexpiprazole)
82VFR53I78 (Aripiprazole)
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Entry Date(s):
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Date Created: 20191129 Date Completed: 20200916 Latest Revision: 20200916
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Update Code:
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20240104
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DOI:
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10.1093/jat/bkz098
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PMID:
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31776574
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Adherence to prescribed antipsychotics is an ongoing problem. Traditionally, estimates of adherence have been made from patient interviews, pill counting and blood testing. A number of methods for the analysis of antipsychotics in blood have been reported for both therapeutic drug monitoring and postmortem testing for toxicity. This report details a dilute and shoot method for the analysis of 19 different antipsychotics and metabolites. The method takes advantage of earlier reports demonstrating unique, prevalent urine metabolites for aripiprazole, brexpiprazole, haloperidol and lurasidone to enhance sensitivity for these analytes. With a fast analysis time and minimal sample preparation, this method can be used for quantitation of antipsychotics in urine. Finally, this method has been used to test samples for over a year with the results summarized in this report. While further improvements are certainly possible, this method is selective and sensitive for this group of important compounds.
(© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
