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Tytuł pozycji:

Immobilization of Fibronectin-Loaded Polyelectrolyte Nanoparticles on Cardiovascular Material Surface to Improve the Biocompatibility.

Tytuł:
Immobilization of Fibronectin-Loaded Polyelectrolyte Nanoparticles on Cardiovascular Material Surface to Improve the Biocompatibility.
Autorzy:
Liu S; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Hu Y; Department of Geriatrics, The Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an 223002, China.
Tao R; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Huo Q; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Wang L; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Tang C; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Pan C; Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, China.
Gong T; Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, China.
Xu N; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Liu T; Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Źródło:
BioMed research international [Biomed Res Int] 2019 Oct 31; Vol. 2019, pp. 5478369. Date of Electronic Publication: 2019 Oct 31 (Print Publication: 2019).
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: New York, NY : Hindawi Pub. Co.
MeSH Terms:
Materials Testing*
Platelet Adhesiveness*
Stents*
Blood Platelets/*metabolism
Coated Materials, Biocompatible/*chemistry
Endothelial Cells/*metabolism
Neointima/*metabolism
Polyelectrolytes/*chemistry
Cell Adhesion ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/pathology ; Coronary Artery Disease/surgery ; Fibronectins ; Heparin/chemistry ; Humans ; Neointima/pathology ; Polylysine/chemistry
References:
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Substance Nomenclature:
0 (Coated Materials, Biocompatible)
0 (Fibronectins)
0 (Polyelectrolytes)
25104-18-1 (Polylysine)
9005-49-6 (Heparin)
Entry Date(s):
Date Created: 20191130 Date Completed: 20200408 Latest Revision: 20200408
Update Code:
20240104
PubMed Central ID:
PMC6875231
DOI:
10.1155/2019/5478369
PMID:
31781622
Czasopismo naukowe
Vascular stent interventional therapy is the main method for clinical treatment of coronary artery diseases. However, due to the insufficient biocompatibility of cardiovascular materials, the implantation of stents often leads to serious adverse cardiac events. Surface biofunctional modification to improve the biocompatibility of vascular stents has been the focus of current research. In this study, based on the structure and function of extracellular matrix on vascular injury healing, a novel fibronectin-loaded poly-l-lysine/heparin nanoparticles was constructed for stent surface modification. In vitro blood compatibility evaluation results showed that the nanoparticles-modified surface could effectively reduce platelet adhesion and activation. In vitro cellular compatibility evaluation results indicated that the nanocoating may provide adequate efficacy in promoting the adhesion and proliferation of endothelial cells and thereby accelerate endothelialization. This study provides a new approach for the surface biological function modification of vascular stents.
Competing Interests: The authors declare there are no conflicts of interest regarding the publication of this paper.
(Copyright © 2019 Shihui Liu et al.)
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