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Tytuł pozycji:

The relationship between urinary kidney injury molecule-1 and blood bone metabolism markers in patients with chronic kidney disease
.

Tytuł :
The relationship between urinary kidney injury molecule-1 and blood bone metabolism markers in patients with chronic kidney disease
.
Autorzy :
Yin C
Cheng C
Wang J
Zhang L
Purrunsing Y
Yang G
Zeng M
Huang H
Ren W
Ye Y
Ma H
Xing C
Wang N
Pokaż więcej
Źródło :
Clinical nephrology [Clin Nephrol] 2020 Feb; Vol. 93 (2), pp. 65-76.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: München-Deisenhofen, Dustri-Verlag Dr. Karl Feistle.
MeSH Terms :
Chronic Kidney Disease-Mineral and Bone Disorder/*urine
Creatinine/*urine
Hepatitis A Virus Cellular Receptor 1/*metabolism
Renal Insufficiency, Chronic/*blood
Renal Insufficiency, Chronic/*urine
Adult ; Alkaline Phosphatase/blood ; Biomarkers/blood ; Biomarkers/urine ; Calcium/blood ; Case-Control Studies ; Chronic Kidney Disease-Mineral and Bone Disorder/blood ; Creatinine/blood ; Cross-Sectional Studies ; Female ; Fibroblast Growth Factors/blood ; Glomerular Filtration Rate ; Glucuronidase/blood ; Humans ; Kidney Failure, Chronic/physiopathology ; Male ; Middle Aged ; Minerals/metabolism ; Parathyroid Hormone/blood ; Phosphorus/blood ; Renal Insufficiency, Chronic/physiopathology ; Urea/blood ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Substance Nomenclature :
0 (Biomarkers)
0 (HAVCR1 protein, human)
0 (Hepatitis A Virus Cellular Receptor 1)
0 (Minerals)
0 (Parathyroid Hormone)
1406-16-2 (Vitamin D)
27YLU75U4W (Phosphorus)
62031-54-3 (Fibroblast Growth Factors)
7Q7P4S7RRE (fibroblast growth factor 23)
8W8T17847W (Urea)
A288AR3C9H (25-hydroxyvitamin D)
AYI8EX34EU (Creatinine)
EC 3.1.3.1 (Alkaline Phosphatase)
EC 3.2.1.31 (Glucuronidase)
EC 3.2.1.31 (klotho protein)
SY7Q814VUP (Calcium)
Entry Date(s) :
Date Created: 20191204 Date Completed: 20200402 Latest Revision: 20200402
Update Code :
20201023
DOI :
10.5414/CN109763
PMID :
31793871
Czasopismo naukowe
Objective: The aim of this study was to evaluate the changes of urinary kidney injury molecule-1(uKIM-1) in chronic kidney disease (CKD) at different stages, and to determine the relationships between uKIM-1 and circulating bone metabolism markers.
Materials and Methods: This cross-sectional study included CKD patients (n = 121) and controls (n = 65). CKD stages were assigned to each individual according to their estimated glomerular filtration rate (eGFR), which was calculated with the modification of diet in renal disease (MDRD) equation. We evaluated the relationships of bone metabolism markers (including calcium, phosphorus, intact parathyroid hormone (iPTH), 25 hydroxy vitamin D (25(OH)D), alkaline phosphatase (ALP), fibroblast growth factor 23 (FGF23), and α-Klotho), uKIM-1, and eGFR. We also compared the levels of bone metabolism markers and uKIM-1 at different CKD stages. The uKIM-1 level was standardized with urine creatinine (uCr).
Results: Compared with healthy controls, CKD patients had higher levels of uKIM-1/uCr, serum creatinine, urea, phosphorus, iPTH, and plasma FGF23, whereas they had lower levels of serum calcium, α-Klotho, and plasma 25(OH)D. In CKD patients, eGFR was positively correlated with levels of serum calcium, α-Klotho, and plasma 25(OH)D, whereas it was negatively correlated with serum phosphorus, iPTH, plasma FGF23, and uKIM-1/uCr. Serum calcium and α-Klotho were significantly decreased in patients with stage 5 CKD compared to those with stage 1 CKD. Serum phosphorus, iPTH, and plasma FGF23 were significantly elevated in patients with stage 4 CKD when compared to those with stage 1 CKD. UKIM-1/uCr was significantly elevated in patients with stage 5 CKD when compared to those with stage 1 CKD. In CKD patients, uKIM-1/uCr levels were positively correlated with levels of serum phosphorus and plasma FGF23, whereas they were negatively correlated with serum calcium and plasma 25(OH)D.
Conclusion: UKIM-1/uCr levels are increased with the deterioration of CKD stage and are correlated with the development of CKD-mineral and bone disorder (CKD-MBD).

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