Maternal glucocorticoids promote offspring growth without inducing oxidative stress or shortening telomeres in wild red squirrels.

Szczegóły
Abstrakt

Tytuł:: Maternal glucocorticoids promote offspring growth without inducing oxidative stress or shortening telomeres in wild red squirrels.
Autorzy:: Dantzer B; Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA .; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA.
van Kesteren F; Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.
Westrick SE; Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA.
Boutin S; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9.
McAdam AG; Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada, N1G 2W1.
Lane JE; Department of Biology, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5E2.
Gillespie R; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Majer A; Department of Biology, Bucknell University, Lewisburg, PA 17837, USA.
Haussmann MF; Department of Biology, Bucknell University, Lewisburg, PA 17837, USA.
Monaghan P; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Źródło:: The Journal of experimental biology [J Exp Biol] 2020 Jan 06; Vol. 223 (Pt 1). Date of Electronic Publication: 2020 Jan 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Publication: London : Company Of Biologists Limited
Original Publication: London, Cambridge Univ. Press.
MeSH Terms:: Oxidative Stress*
Telomere Shortening*
Glucocorticoids/*metabolism
Sciuridae/*physiology
Animals ; Female ; Male ; Sciuridae/growth & development
References:: Nature. 1970 Jun 13;226(5250):1058-9. (PMID: 5447019)
Biol Lett. 2017 Dec;13(12):. (PMID: 29212750)
Proc Biol Sci. 2015 May 7;282(1806):20150209. (PMID: 25833848)
Ecol Evol. 2016 Mar 21;6(9):2833-42. (PMID: 27217942)
Ecol Lett. 2009 Jan;12(1):75-92. (PMID: 19016828)
Mol Ecol Resour. 2008 Mar;8(2):264-74. (PMID: 21585768)
Horm Behav. 2011 Mar;59(3):279-89. (PMID: 20591431)
Lancet. 2003 Feb 1;361(9355):393-5. (PMID: 12573379)
Proc Biol Sci. 2014 Mar 19;281(1782):20133151. (PMID: 24648221)
Am J Obstet Gynecol. 2016 Jul;215(1):94.e1-8. (PMID: 26829506)
Nature. 1990 May 31;345(6274):458-60. (PMID: 2342578)
Biol Lett. 2005 Jun 22;1(2):212-4. (PMID: 17148169)
Endocr Rev. 2000 Feb;21(1):55-89. (PMID: 10696570)
Proc Biol Sci. 2009 May 7;276(1662):1679-83. (PMID: 19324831)
Early Hum Dev. 2015 Nov;91(11):643-7. (PMID: 26385447)
Proc Biol Sci. 2009 Mar 22;276(1659):1129-35. (PMID: 19129116)
Trends Ecol Evol. 2012 Oct;27(10):570-7. (PMID: 22789512)
J Neurosci. 1996 Jun 15;16(12):3943-9. (PMID: 8656288)
Proc Biol Sci. 2014 Apr 30;281(1785):20133287. (PMID: 24789893)
Am Nat. 2018 Nov;192(5):593-604. (PMID: 30332583)
Biol Lett. 2007 Apr 22;3(2):128-30. (PMID: 17264051)
Neuroscience. 1997 Aug;79(4):1005-12. (PMID: 9219963)
Science. 1998 Jan 16;279(5349):349-52. (PMID: 9454332)
Proc Biol Sci. 2013 Sep 07;280(1766):20131343. (PMID: 23843395)
Proc Biol Sci. 2009 Sep 7;276(1670):3157-65. (PMID: 19520803)
Evolution. 2013 May;67(5):1527-36. (PMID: 23617928)
Biol Lett. 2012 Dec 23;8(6):1063-6. (PMID: 23054915)
FEBS Lett. 2005 Feb 7;579(4):859-62. (PMID: 15680963)
Biol Lett. 2015 Nov;11(11):. (PMID: 26538535)
Science. 2007 Nov 16;318(5853):1134-6. (PMID: 18006745)
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):E513-8. (PMID: 21813766)
Mech Ageing Dev. 2000 Nov 15;119(3):89-99. (PMID: 11080530)
Brain Behav Immun. 2005 Jul;19(4):296-308. (PMID: 15944068)
Trends Biochem Sci. 2002 Jul;27(7):339-44. (PMID: 12114022)
Biol Lett. 2014 Dec;10(12):20140834. (PMID: 25519754)
Physiol Biochem Zool. 2019 Sep/Oct;92(5):445-458. (PMID: 31365306)
Evolution. 2002 Apr;56(4):846-51. (PMID: 12038543)
Stress. 2011 Nov;14(6):677-84. (PMID: 21875305)
Nat Rev Neurosci. 2009 Jun;10(6):434-45. (PMID: 19401723)
Physiol Rev. 1998 Apr;78(2):547-81. (PMID: 9562038)
Biol Rev Camb Philos Soc. 2016 May;91(2):483-97. (PMID: 25765468)
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):. (PMID: 29335370)
Conserv Physiol. 2015 Mar 11;3(1):cov007. (PMID: 27293692)
Science. 2006 Dec 22;314(5807):1928-30. (PMID: 17185600)
Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180117. (PMID: 30966876)
Horm Behav. 2010 Nov;58(5):769-79. (PMID: 20688070)
Proc Biol Sci. 2012 Apr 7;279(1732):1447-56. (PMID: 22072607)
Proc Biol Sci. 2016 Sep 28;283(1839):. (PMID: 27655764)
J Anim Ecol. 2015 Jan;84(1):249-59. (PMID: 25132293)
Proc Biol Sci. 2012 Dec 12;280(1752):20122370. (PMID: 23235704)
Nat Neurosci. 2004 Aug;7(8):847-54. (PMID: 15220929)
Nat Commun. 2019 Oct 17;10(1):4723. (PMID: 31624261)
Proc Biol Sci. 2003 Jul 7;270(1522):1387-92. (PMID: 12965030)
J Comp Physiol B. 2011 May;181(4):447-56. (PMID: 21416253)
Trends Ecol Evol. 2001 May 1;16(5):254-260. (PMID: 11301155)
Bioessays. 2012 Nov;34(11):943-52. (PMID: 22991129)
Science. 2013 Jun 7;340(6137):1215-7. (PMID: 23599265)
Free Radic Biol Med. 2008 Feb 1;44(3):235-46. (PMID: 18021748)
Cell. 1999 Mar 5;96(5):701-12. (PMID: 10089885)
Physiol Behav. 1976 Dec;17(6):1019-21. (PMID: 14677599)
Ageing Res Rev. 2015 Nov;24(Pt B):191-6. (PMID: 26304838)
Med Hypotheses. 2016 May;90:41-7. (PMID: 27063083)
Physiol Rev. 2008 Apr;88(2):557-79. (PMID: 18391173)
Integr Comp Biol. 2017 Sep 1;57(3):437-449. (PMID: 28957523)
Exp Gerontol. 2015 Nov;71:38-47. (PMID: 26348426)
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):. (PMID: 29335369)
Am Nat. 2008 Oct;172(4):E135-49. (PMID: 18793091)
Can J Physiol Pharmacol. 2009 Jun;87(6):440-7. (PMID: 19526038)
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10658-E10666. (PMID: 29180423)
Trends Ecol Evol. 2006 Jan;21(1):47-53. (PMID: 16701469)
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3309-13. (PMID: 10716732)
Grant Information:: R15 HD083870 United States HD NICHD NIH HHS
Contributed Indexing:: Keywords: Developmental plasticity; Life history; Maternal effects; Tamiasciurus hudsonicus
Molecular Sequence:: figshare 10.6084/m9.figshare.10286060.v1; 10.6084/m9.figshare.10285148.v1; 10.6084/m9.figshare.10285085.v1; 10.6084/m9.figshare.10284188.v1
Substance Nomenclature:: 0 (Glucocorticoids)
Entry Date(s):: Date Created: 20191205 Date Completed: 20201109 Latest Revision: 20231126
Update Code:: 20240104
PubMed Central ID:: PMC10668338
DOI:: 10.1242/jeb.212373
PMID:: 31796605
: Czasopismo naukowe

Elevations in glucocorticoid (GC) levels in breeding females may induce adaptive shifts in offspring life histories. Offspring produced by mothers with elevated GCs may be better prepared to face harsh environments, where a faster pace of life is beneficial. We examined how experimentally elevated GCs in pregnant or lactating North American red squirrels ( Tamiasciurus hudsonicus ) affected offspring postnatal growth, structural size and oxidative stress levels (two antioxidants and oxidative protein damage) in three different tissues (blood, heart and liver) and liver telomere lengths. We predicted that offspring from mothers treated with GCs would grow faster but would also have higher levels of oxidative stress and shorter telomeres, which may predict reduced longevity. Offspring from mothers treated with GCs during pregnancy were 8.3% lighter around birth but grew (in body mass) 17.0% faster than those from controls, whereas offspring from mothers treated with GCs during lactation grew 34.8% slower than those from controls and did not differ in body mass around birth. Treating mothers with GCs during pregnancy or lactation did not alter the oxidative stress levels or telomere lengths of their offspring. Fast-growing offspring from any of the treatment groups did not have higher oxidative stress levels or shorter telomere lengths, indicating that offspring that grew faster early in life did not exhibit oxidative costs after this period of growth. Our results indicate that elevations in maternal GCs may induce plasticity in offspring growth without long-term oxidative costs to the offspring that might result in a shortened lifespan.
Competing Interests: Competing interestsThe authors declare no competing or financial interests.
(© 2020. Published by The Company of Biologists Ltd.)

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