Prognostic Factors in CCHF - An Indian Origin Study.

Background and Objectives: CCHF is an emerging zoonotic Viral haemorrhagic illness in indian setup after dengue and KFD. It is known for its high mortality and high potential for nosocomial spread. After detection of the first confirmed case from Ahmedabad-Gujarat in 2011, there are so many cases detected from other area of Gujarat and Nearby Rajasthan state. Several studies have been performed to anticipate the severity of the disease from other countries where it is already an endemic disease. Aim of our study is to re-evaluate the predictors of fatality in confirmed cases of CCHF.
Methods: In our retrospective and observational study, total 12 (Twelve) RT- PCR confirmed cases were included. Out of that, 8 (eight) patients survived while 4 (four) patients died. We compared clinical and laboratory parameters among survived and died. Because of small sample size, no appropriate statistical method can be used.
Results and Conclusion: Marked difference noted between two groups in Aptt prolongation, INR elevation, ALT level, S.Fibrinogen, CCHF IgM positivity, major bleeding symptoms and CNS involvement while no such major difference seen in other parameters like platelet count, total WBC count and other clinical parameters. Further study with large sample size from indian patients needed to confirm above findings.
(© Journal of the Association of Physicians of India 2011.)