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Tytuł pozycji:

Epigenetic modifications working in the decidualization and endometrial receptivity.

Tytuł:
Epigenetic modifications working in the decidualization and endometrial receptivity.
Autorzy:
Liu H; Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Rd, Wuhan, 430030, People's Republic of China.
Huang X; Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Rd, Wuhan, 430030, People's Republic of China.
Mor G; Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Rd, Wuhan, 430030, People's Republic of China.; Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University, Detroit, USA.
Liao A; Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Rd, Wuhan, 430030, People's Republic of China. aihua_.
Źródło:
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Jun; Vol. 77 (11), pp. 2091-2101. Date of Electronic Publication: 2019 Dec 07.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: Basel : Springer
Original Publication: Basel ; Boston : Birkhauser, c1997-
MeSH Terms:
Epigenesis, Genetic*
Decidua/*physiology
Endometrium/*physiology
Animals ; DNA Methylation ; Decidua/cytology ; Endometrium/cytology ; Female ; Histone Code ; Humans ; Pregnancy ; Stromal Cells/cytology ; Stromal Cells/metabolism
Grant Information:
NO. 81871186 National Natural Science Foundation of China; 2018YFC1003900 National Basic Research Program of China (973 Program); 2018YFC1003904 National Basic Research Program of China (973 Program)
Contributed Indexing:
Keywords: DNA methylation; Decidualization; Histone modification; Human endometrial stromal cells; Non-coding RNAs
Entry Date(s):
Date Created: 20191209 Date Completed: 20200615 Latest Revision: 20200615
Update Code:
20240104
DOI:
10.1007/s00018-019-03395-9
PMID:
31813015
Czasopismo naukowe
Decidualization is a critical event for the blastocyst implantation, placental development and fetal growth and the normal term. In mice, the embryo implantation to the uterine epithelial would trigger the endometrial stromal cells to differentiate into decidual stromal cells. However, decidualization in women takes place from the secretory phase of each menstrual cycle and continues to early pregnancy if there is conceptus. Deficient decidualization is often associated with pregnancy specific complications and reproductive disorders. Dramatic changes occur in the gene expression profiles during decidualization, which is coordinately regulated by steroid hormones, growth factors, and molecular and epigenetic mechanisms. Recently, emerging evidences showed that epigenetic modifications, mainly including DNA methylation, histone modification, and non-coding RNAs, play an important role in the decidualization process via affecting the target genes' expression. In this review, we will focus on the epigenetic modifications in decidualization and open novel avenues to predict and treat the pregnancy complications caused by abnormal decidualization.

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