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Tytuł pozycji:

Noncardiac-Related Morbidity, Mobility Limitation, and Outcomes in Older Adults With Heart Failure.

Tytuł:
Noncardiac-Related Morbidity, Mobility Limitation, and Outcomes in Older Adults With Heart Failure.
Autorzy:
Tisminetzky M; Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.; Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester.; Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.
Gurwitz JH; Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.; Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester.; Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.
Fan D; Division of Research, Kaiser Permanente Northern California, Oakland.
Reynolds K; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena.
Smith DH; Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
Fouayzi H; Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.
Sung SH; Division of Research, Kaiser Permanente Northern California, Oakland.
Goldberg R; Meyers Primary Care Institute, A Joint Endeavor of University of Massachusetts Medical School, Reliant Medical Group, and Fallon Health, Worcester, Massachusetts.; Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester.
Go AS; Division of Research, Kaiser Permanente Northern California, Oakland.; Department of Epidemiology and University of California, San Francisco.; Department of Biostatistics and University of California, San Francisco.; Department of Medicine, University of California, San Francisco.; Department of Medicine, Stanford University, California.; Department of Health Research and Policy, Stanford University, California.
Źródło:
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2020 Sep 25; Vol. 75 (10), pp. 1981-1988.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
Język:
English
Imprint Name(s):
Publication: Washington, DC : published on behalf of the Gerontological Society of America by Oxford University Press
Original Publication: Washington, DC : Gerontological Society of America, c1995-
MeSH Terms:
Mobility Limitation*
Heart Failure/*epidemiology
Morbidity/*trends
Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Retrospective Studies ; Risk Factors ; United States/epidemiology
References:
Arch Intern Med. 2008 Dec 8;168(22):2415-21. (PMID: 19064823)
PLoS One. 2012;7(8):e41601. (PMID: 22870234)
J Gen Intern Med. 2012 May;27(5):513-9. (PMID: 22095572)
Cancer. 2016 Dec 15;122(24):3776-3784. (PMID: 27518165)
Colorectal Dis. 2017 Jun;19(6):O210-O218. (PMID: 28304120)
J Am Coll Cardiol. 2012 Mar 13;59(11):998-1005. (PMID: 22402071)
J Am Geriatr Soc. 2018 Jul;66(6):1101-1107. (PMID: 29603724)
Expert Rev Cardiovasc Ther. 2008 Sep;6(8):1043-5. (PMID: 18793105)
J Gen Intern Med. 2012 Sep;27(9):1171-9. (PMID: 22549300)
BMJ. 2003 Sep 6;327(7414):513-4. (PMID: 12958085)
Med Care. 2018 Feb;56(2):193-201. (PMID: 29271820)
J Am Coll Cardiol. 2010 Jan 26;55(4):309-16. (PMID: 20117435)
Am J Epidemiol. 2009 Nov 15;170(10):1290-9. (PMID: 19808632)
J Gerontol A Biol Sci Med Sci. 2015 May;70(5):545-53. (PMID: 24963155)
JAMA. 2006 Nov 1;296(17):2105-11. (PMID: 17077375)
JAMA. 2010 Nov 3;304(17):1950-1. (PMID: 21045104)
Circ Cardiovasc Qual Outcomes. 2008 Nov;1(2):138-47. (PMID: 20031802)
J Am Geriatr Soc. 2016 Jul;64(7):1469-74. (PMID: 27348135)
J Am Coll Cardiol. 2003 Oct 1;42(7):1226-33. (PMID: 14522486)
J Am Geriatr Soc. 2013 Jan;61(1):26-33. (PMID: 23311550)
Aging Clin Exp Res. 2008 Jun;20(3):181-8. (PMID: 18594183)
Circulation. 2006 Jun 13;113(23):2713-23. (PMID: 16754803)
Am Heart J. 2002 Mar;143(3):412-7. (PMID: 11868045)
J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):M691-7. (PMID: 11078100)
J Intern Med. 1997 May;241(5):387-94. (PMID: 9183306)
J Am Geriatr Soc. 2007 Jan;55(1):29-34. (PMID: 17233682)
Med Care. 2014 Mar;52 Suppl 3:S75-84. (PMID: 24561763)
Issue Brief (Commonw Fund). 2016 Aug;26:1-14. (PMID: 27571599)
Int J Cardiol. 2018 Nov 15;271:132-139. (PMID: 30482453)
Circ Cardiovasc Qual Outcomes. 2016 Jan;9(1):23-30. (PMID: 26715650)
Grant Information:
R01 AG062630 United States AG NIA NIH HHS; U19 HL091179 United States HL NHLBI NIH HHS; RC1 HL099395 United States HL NHLBI NIH HHS; R33 AG057806 United States AG NIA NIH HHS; R24 AG045050 United States AG NIA NIH HHS
Contributed Indexing:
Keywords: Mobility impairment; Mortality; Multimorbidity
Entry Date(s):
Date Created: 20191210 Date Completed: 20210216 Latest Revision: 20210320
Update Code:
20240104
PubMed Central ID:
PMC7518555
DOI:
10.1093/gerona/glz285
PMID:
31813983
Czasopismo naukowe
Background: To examine the individual and combined associations of noncardiac-related conditions and mobility limitation with morbidity and mortality in adults with heart failure (HF).
Methods: We conducted a retrospective cohort study in a large, diverse group of adults with HF from five U.S. integrated healthcare delivery systems. We characterized patients with respect to the presence of noncardiac conditions (<3 vs ≥3) and/or mobility impairment (defined by the use/nonuse of a wheelchair, cane, or walker), categorizing them into four subgroups. Outcomes included all-cause death and hospitalizations for HF or any cause.
Results: Among 114,553 adults diagnosed with HF (mean age: 73 years old, 46% women), compared with <3 noncardiac conditions/no mobility limitation, adjusted hazard ratios (HR) for all-cause death among those with <3 noncardiac conditions/mobility limitation, ≥3 noncardiac conditions/no mobility limitation, ≥3 noncardiac conditions/mobility limitation (vs) were 1.40 (95% CI, 1.31-1.51), 1.72 (95% CI, 1.69-1.75), and 1.93 (95% CI, 1.85-2.01), respectively. We did not observe an increased risk of any-cause or HF-related hospitalization related to the presence of mobility limitation among those with a greater burden of noncardiac multimorbidity. Consistent findings regarding mortality were observed within groups defined according to age, gender, and HF type (preserved, reduced, mid-range ejection fraction), with the most prominent impact of mobility limitation in those <65 years of age.
Conclusions: There is an additive association of mobility limitation, beyond the burden of noncardiac multimorbidity, on mortality for patients with HF, and especially prominent in younger patients.
(© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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