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Tytuł:
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Chemical constituents from Artemisia vulgaris and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.
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Autorzy:
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Omar AM; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Dibwe DF; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Tawila AM; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Sun S; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Kim MJ; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Awale S; Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
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Źródło:
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Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (22), pp. 4279-4285. Date of Electronic Publication: 2019 Dec 07.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
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MeSH Terms:
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Antineoplastic Agents, Phytogenic*/pharmacology
Antineoplastic Agents, Phytogenic*/therapeutic use
Artemisia*
Pancreatic Neoplasms*/drug therapy
Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure
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Contributed Indexing:
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Keywords: Artemisia vulgaris; ECD calculation; anti-austerity; sesquiterpene
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Substance Nomenclature:
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0 (Antineoplastic Agents, Phytogenic)
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Entry Date(s):
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Date Created: 20191210 Date Completed: 20211123 Latest Revision: 20211123
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Update Code:
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20240105
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DOI:
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10.1080/14786419.2019.1700246
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PMID:
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31814438
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The 70% ethanolic extract of Artemisia vulgaris showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition with PC 50 12.5 μg/mL. A phytochemical investigation of this extract yielded a new bicyclic [4:3:0] sesquiterpene named (+)-vulgaric acid ( 1 ), together with eight previously reported compounds. The structural elucidation of 1 was achieved by HRFABMS and NMR analysis. The absolute configuration of 1 was deduced by computational calculations of ECD data. All isolated compounds were tested for preferential cytotoxicity against PANC-1 cells, and apigenin ( 3 ) showed the strongest activity with PC 50 30.7 μM.
