Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population.

Tytuł:: Association of Melatonin Pathway Gene's Single-Nucleotide Polymorphisms with Systemic Lupus Erythematosus in a Chinese Population.
Autorzy:: Wang P; Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, Jiangsu, China.; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.
Liu L; Department of Parasitology, Medical College of Soochow University, 199 Renai Road, Suzhou, Jiangsu, China.
Zhao LF; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Zhao CN; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Mao YM; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Dan YL; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Wu Q; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Li XM; Department of Rheumatology and Immunology, Anhui Provincial Hospital, 17 Lujiang Road, Hefei, Anhui, China.
Wang DG; Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Pan HF; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China.; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Źródło:: Journal of immunology research [J Immunol Res] 2019 Nov 13; Vol. 2019, pp. 2397698. Date of Electronic Publication: 2019 Nov 13 (Print Publication: 2019).
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Cairo, Egypt : Hindawi Publishing Corporation, [2014]-
MeSH Terms:: Polymorphism, Single Nucleotide*
Arylalkylamine N-Acetyltransferase/*genetics
Lupus Erythematosus, Systemic/*genetics
Melatonin/*metabolism
Receptor, Melatonin, MT1/*genetics
Receptor, Melatonin, MT2/*genetics
Adult ; Arylalkylamine N-Acetyltransferase/metabolism ; Asian People ; Case-Control Studies ; Female ; Gene Expression ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Lupus Erythematosus, Systemic/ethnology ; Lupus Erythematosus, Systemic/metabolism ; Lupus Erythematosus, Systemic/pathology ; Male ; Middle Aged ; Receptor, Melatonin, MT1/metabolism ; Receptor, Melatonin, MT2/metabolism
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Substance Nomenclature:: 0 (MTNR1A protein, human)
0 (MTNR1B protein, human)
0 (Receptor, Melatonin, MT1)
0 (Receptor, Melatonin, MT2)
EC 2.3.1.87 (AANAT protein, human)
EC 2.3.1.87 (Arylalkylamine N-Acetyltransferase)
JL5DK93RCL (Melatonin)
Entry Date(s):: Date Created: 20191210 Date Completed: 20200429 Latest Revision: 20221207
Update Code:: 20240105
PubMed Central ID:: PMC6877953
DOI:: 10.1155/2019/2397698
PMID:: 31815152
: Czasopismo naukowe

Pełny tekst

Objectives: This study was to investigate the association of melatonin (MTN) pathway gene's single-nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE).
Methods: We recruited 495 SLE patients and 493 healthy controls, 11 tag SNPs in MTN receptor 1a ( MTNR1a ), MTNR1b , and arylalkylamine N-acetyltransferase ( AANAT ) genes were genotyped and analyzed. Serum MTN concentration was determined by enzyme-linked immunosorbent assay (ELISA) kits.
Results: Two SNPs of AANAT gene (rs8150 and rs3760138) associated with the risk of SLE; CC carriers of rs8150 had a lower risk as compared to GG (OR = 0.537, 95% CI: 0.361, 0.799), whereas GG carrier in rs3760138 had an increased risk (OR = 1.823, 95% CI: 1.154, 2.880) compared to TT. However, we did not find any genetic association between the other nine SNPs with SLE risk. Case-only analysis showed associations of rs2165667 and rs1562444 with arthritis, rs10830962 with malar rash, rs3760138 with immunological abnormality, and rs8150 with hematological abnormality. Furthermore, a significant difference between plasma MTN levels with different genotypes of rs1562444 was observed. Haplotype analyses revealed that haplotype of CCTAT, CTAGT, and GGG was significantly associated with the increased risk in SLE susceptibility, but TCTAT and CTG appeared to be a protective haplotype.
Conclusions: The present study supported the genetic association of MTN pathway genes with SLE susceptibility and specific clinical manifestations, suggesting the potential role of MTN pathway genes in the pathogenesis and development of SLE.
Competing Interests: The authors confirm that there are no conflicts of interest.
(Copyright © 2019 Peng Wang et al.)

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