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Tytuł:
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Maternal exposure to air pollution and the risk of small for gestational age in offspring: A population-based study in Taiwan.
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Autorzy:
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Huang CY; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Liu CL; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
Chen MH; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Pediatrics, National Taiwan University Hospital Yun-Lin Branch, Yunlin County, Taiwan.
Tsao PN; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; The Research Center of Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
Chen CY; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Chou HC; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: .
Chen PC; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Innovation and Policy Center for Population Health and Sustainable Environment, National Taiwan University College of Public Health, Taipei, Taiwan. Electronic address: .
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Źródło:
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Pediatrics and neonatology [Pediatr Neonatol] 2020 Apr; Vol. 61 (2), pp. 231-237. Date of Electronic Publication: 2019 Nov 22.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: [Singapore] : Elsevier
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MeSH Terms:
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Infant, Small for Gestational Age*
Air Pollution/*adverse effects
Maternal Exposure/*adverse effects
Adult ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Lead/adverse effects ; Particulate Matter/adverse effects ; Pregnancy ; Risk
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Contributed Indexing:
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Keywords: air pollution; lead; pregnancy; small for gestational age
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Substance Nomenclature:
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0 (Particulate Matter)
2P299V784P (Lead)
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Entry Date(s):
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Date Created: 20191211 Date Completed: 20201006 Latest Revision: 20201006
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Update Code:
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20240105
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DOI:
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10.1016/j.pedneo.2019.11.008
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PMID:
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31818536
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Background: Exposure to air pollution has been associated with a wide range of adverse health effects; however, few studies addressed the relationship between ambient particulate matter as well as the compositions in particulate matter such as lead and the risk of small for gestational age (SGA) in offspring. The aim of this study is to investigate the effect of maternal exposure to criteria air pollutants and the lead in total suspended particulate matter during pregnancy on SGA births in Taiwan.
Methods: This population study consisted of 322,513 singleton live births in Taiwan between 1996 and 2002. Daytime (7 AM-7 PM) exposure to particulate matter ≤10 μm (PM 10 ), carbon monoxide (CO), sulfur dioxide (SO 2 ), nitrogen dioxide (NO 2 ) and ozone (O 3 ), and monthly exposure to lead in total suspended particles (TSP) during each trimester were estimated. Generalized additive model (GAM) was used to assess the association between maternal exposure to particulate air pollutants and SGA births, taking into account potential confounders and gaseous air pollutants.
Results: We found significant association between the highest quartile (≥75th) of maternal PM 10 exposure and SGA and demonstrated a significant exposure-response relationship. Furthermore, the highest quartile (≥75th) of maternal lead exposure was also associated with SGA during the second and third trimester of pregnancy, and there was a significant exposure-response relationship between maternal lead exposure and SGA during pregnancy.
Conclusion: Maternal exposure to PM 10 and lead in total suspended particulate matter during pregnancy was associated with an increased risk of SGA in offspring.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest relevant to this article.
(Copyright © 2019. Published by Elsevier B.V.)
