-
Tytuł:
-
The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study.
-
Autorzy:
-
Helill SE; Department of Anesthesia,College of Medicine and Health Sciences,Wachemo University, Hossana, Ethiopia.
Sahile WA; Department of Anesthesia, School of Medicine, Addis Ababa University Addis, Addis Ababa, Ethiopia.
Abdo RA; Department of Midwifery,College of Medicine and Health Sciences,Wachemo University, Hossana, Ethiopia.
Wolde GD; Department of Anesthesia, School of Medicine, Wolaita Sodo University, Wolaita, Ethiopia.
Halil HM; Department of Midwifery,College of Medicine and Health Sciences,Wachemo University, Hossana, Ethiopia.
-
Źródło:
-
PloS one [PLoS One] 2019 Dec 12; Vol. 14 (12), pp. e0226030. Date of Electronic Publication: 2019 Dec 12 (Print Publication: 2019).
-
Typ publikacji:
-
Journal Article; Research Support, Non-U.S. Gov't
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: San Francisco, CA : Public Library of Science
-
MeSH Terms:
-
Anesthesia, Spinal*/adverse effects
Cesarean Section*/adverse effects
Cesarean Section*/methods
Blood Pressure/*drug effects
Bupivacaine/*administration & dosage
Hemodynamics/*drug effects
Adult ; Anesthesia, Obstetrical ; Bupivacaine/adverse effects ; Cohort Studies ; Elective Surgical Procedures/adverse effects ; Ethiopia ; Female ; Humans ; Hypotension/chemically induced ; Hypotension/physiopathology ; Injections, Spinal/adverse effects ; Pregnancy ; Prospective Studies ; Treatment Outcome ; Young Adult
-
References:
-
Curr Opin Anaesthesiol. 2008 Dec;21(6):723-8. (PMID: 19009687)
Anesth Analg. 2011 Oct;113(4):811-7. (PMID: 21890887)
Anaesthesia. 1999 May;54(5):469-74. (PMID: 10995146)
Br J Anaesth. 2001 Mar;86(3):372-6. (PMID: 11573527)
Can J Anaesth. 2007 Apr;54(4):290-5. (PMID: 17400981)
Anesth Analg. 2002 Jun;94(6):1521-9, table of contents. (PMID: 12032019)
Med Arh. 2010;64(1):11-4. (PMID: 20422816)
Kaohsiung J Med Sci. 2004 Sep;20(9):423-30. (PMID: 15506554)
J Clin Monit Comput. 2009 Apr;23(2):85-92. (PMID: 19277879)
Anesth Analg. 2005 Apr;100(4):1159-65. (PMID: 15781538)
Best Pract Res Clin Anaesthesiol. 2003 Sep;17(3):335-46. (PMID: 14529006)
Iran J Med Sci. 2017 Mar;42(2):136-143. (PMID: 28360439)
Acta Anaesthesiol Scand. 2005 Feb;49(2):170-6. (PMID: 15715617)
Turk J Med Sci. 2014;44(2):224-31. (PMID: 25566589)
Anesthesiology. 1999 Nov;91(5):1260-6. (PMID: 10551575)
Anesth Analg. 2009 Oct;109(4):1219-24. (PMID: 19641050)
Anesth Analg. 1998 Aug;87(2):336-40. (PMID: 9706927)
Can J Anaesth. 2008 Aug;55(8):501-6. (PMID: 18676384)
-
Substance Nomenclature:
-
Y8335394RO (Bupivacaine)
-
Entry Date(s):
-
Date Created: 20191213 Date Completed: 20200401 Latest Revision: 20200401
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC6907792
-
DOI:
-
10.1371/journal.pone.0226030
-
PMID:
-
31830074
-
Background: Spinal anesthesia is a form of regional anesthesia frequently used in various lower abdominal, orthopedic, obstetric operations such as a cesarean delivery. The most common local anesthetic used for spinal anesthesia in obstetric and non-obstetric surgery is bupivacaine which can be utilized as an isobaric or hyperbaric solution, producing differences in maternal hemodynamic changes. Against this backdrop, the study aims to compare the effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic alterations after administering spinal anesthesia for elective cesarean delivery at Gandhi Memorial Hospital, Addis Ababa, Ethiopia.
Methods: A hospital-based prospective cohort study design was employed for the period December 1, 2017 to January 30, 2018. A total of 100 parturient were involved, with one group exposed to isobaric bupivacaine and the other to hyperbaric bupivacaine to observe their effects on maternal hemodynamic changes post spinal anesthesia. The participants were selected through systematic random sampling. Data analysis was performed using SPSS (version 20) through descriptive statistic, independent sample t-test, Mann-Whitney U-test, Fisher's exact test, and Chi-square test were used. P values of <0.05 was assumed as statistically significant for all tests.
Results: The incidence of hypotension was found to be greater in isobaric than hyperbaric groups (82% vs. 60% respectively; p = 0.015). No statistical significant differences were found in mean arterial pressure value at baseline, but, statistically significant changes were observed among the groups (p <0.05) at all study timing after spinal anesthesia, except at 30thmin. No statistically significant differences were seen in the mean heart rate variability after spinal anesthesia at all periods, except the 15th minute (p = 0.033). A greater rate of vasopressor was used in the isobaric group as compared to the hyperbaric group (36% vs. 14% respectively; p = 0.011).
Conclusion: Baricity is a significant factor in maternal hemodynamic changes in the parturient for elective cesarean section. Isobaric bupivacaine produces greater change in blood pressure and incidence of hypotension and entails a greater vasopressor requirement than hyperbaric bupivacaine after spinal anesthesia for elective cesarean section.
Competing Interests: The authors have declared that no competing interests exist.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.
