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Tytuł:
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Body mass index as a tool for optimizing surgical care in coronary artery bypass grafting through understanding risks of specific complications.
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Autorzy:
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Nishioka N; Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
Ichihara N; Department of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Bando K; Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan. Electronic address: .
Motomura N; Japan Cardiovascular Surgery Database-Adult Section.
Koyama N; Japan Cardiovascular Surgery Database-Adult Section.
Miyata H; Department of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Japan Cardiovascular Surgery Database-Adult Section; Department of Health Policy and Management, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Kohsaka S; Department of Healthcare Quality Assessment, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan; Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Takamoto S; Japan Cardiovascular Surgery Database-Adult Section.
Hashimoto K; Department of Cardiac Surgery, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.
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Źródło:
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The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2020 Aug; Vol. 160 (2), pp. 409-420.e14. Date of Electronic Publication: 2019 Sep 28.
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Typ publikacji:
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Journal Article; Observational Study
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Język:
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English
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Imprint Name(s):
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Publication: St. Louis, MO : Mosby
Original Publication: St. Louis.
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MeSH Terms:
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Body Mass Index*
Coronary Artery Bypass/*adverse effects
Coronary Artery Disease/*surgery
Obesity/*diagnosis
Postoperative Complications/*etiology
Thinness/*diagnosis
Aged ; Aged, 80 and over ; Coronary Artery Bypass/mortality ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/mortality ; Databases, Factual ; Female ; Humans ; Japan ; Male ; Middle Aged ; Obesity/complications ; Obesity/mortality ; Postoperative Complications/mortality ; Postoperative Complications/therapy ; Retreatment ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Thinness/complications ; Thinness/mortality ; Time Factors ; Treatment Outcome
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Contributed Indexing:
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Keywords: body mass index; coronary artery bypass grafting; morbidity; operative mortality
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Entry Date(s):
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Date Created: 20191214 Date Completed: 20200803 Latest Revision: 20200803
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Update Code:
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20240105
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DOI:
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10.1016/j.jtcvs.2019.07.048
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PMID:
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31831196
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Objectives: To investigate the relationship between body mass index (BMI) and early outcomes, and specific types of morbidities associated with low and high BMI, in patients undergoing coronary artery bypass grafting.
Methods: This was a retrospective study on isolated coronary artery bypass grafting patients (aged ≥60 years) between 2008 and 2017 in the Japan Cardiovascular Surgery Database. The primary end point was defined as operative mortality. The secondary end point was combined morbidity (ie, operative mortality, reoperation for bleeding, stroke, new onset of hemodialysis, mediastinitis, and prolonged ventilation). Patient characteristics and outcomes were compared among BMI groups. Spline curves were fit between BMI and outcomes. Multivariable logistic regression models with categorized BMI and generalized additive models with spline-transformed BMI were used to estimate and visualize the effect of BMI adjusted for other covariates.
Results: A total of 96,058 patients were included in the analysis. Low (<18.5) and high (≥30) BMI were both associated with a higher risk of mortality (low: adjusted odds ratio, 1.34; 95% confidence interval, 1.16-1.54; P < .0001, and high: adjusted odds ratio, 2.10; 95% confidence interval, 1.70-2.59; P < .0001) and combined morbidity (low: adjusted odds ratio, 1.18; 95% confidence interval, 1.08-1.29; P = .0002 and high: adjusted odds ratio, 1.82; 95% confidence interval, 1.63-2.03; P < .0001). Low and high BMI were associated with different types of morbidities. In models using spline transformation, the deviation of BMI from a proximately 21 to 23 was proportionally associated with increased risk.
Conclusions: In patients undergoing coronary artery bypass grafting, low and high BMI were risk factors of mortality associated with different types of morbidities, which may warrant tailored preventive approaches.
(Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
Comment in: J Thorac Cardiovasc Surg. 2020 Aug;160(2):423-424. (PMID: 31540734)
Comment in: J Thorac Cardiovasc Surg. 2020 Aug;160(2):421-422. (PMID: 31562012)
