-
Tytuł:
-
An enzyme-initiated DNAzyme motor for RNase H activity imaging in living cell.
-
Autorzy:
-
Hu N; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Wang Y; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Liu C; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
He M; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Nie C; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Zhang J; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Yu Q; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Zhao C; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Chen T; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
Chu X; Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. .
-
Źródło:
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Jan 14; Vol. 56 (4), pp. 639-642. Date of Electronic Publication: 2019 Dec 13.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Cambridge : Royal Society of Chemistry
-
MeSH Terms:
-
Optical Imaging*
DNA, Catalytic/*metabolism
Ribonuclease H/*metabolism
Cell Survival ; HeLa Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Microscopy, Confocal ; Microscopy, Fluorescence
-
Substance Nomenclature:
-
0 (DNA, Catalytic)
EC 3.1.26.4 (Ribonuclease H)
-
Entry Date(s):
-
Date Created: 20191214 Date Completed: 20200212 Latest Revision: 20200212
-
Update Code:
-
20240105
-
DOI:
-
10.1039/c9cc08692g
-
PMID:
-
31833487
-
In this work, we have developed a novel DNAzyme motor initiated by endogenous enzyme for sensitive imaging of intracellular RNase H activity.