Gender of offspring and risk of ovarian cancer: The HOPE study.

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Tytuł:: Gender of offspring and risk of ovarian cancer: The HOPE study.
Autorzy:: Fu Z; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: .
Moysich K; Roswell Park Cancer Institute, Buffalo, NY, USA. Electronic address: .
Ness RB; University of Texas School of Public Health, Houston, TX, USA. Electronic address: .
Modugno F; Womens Cancer Research Program, Magee-Womens Research Institute and UPMC Hillman Cancer Center, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: .
Źródło:: Cancer epidemiology [Cancer Epidemiol] 2020 Feb; Vol. 64, pp. 101646. Date of Electronic Publication: 2019 Dec 10.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język:: English
Imprint Name(s):: Original Publication: Amsterdam : Elsevier
MeSH Terms:: Ovarian Neoplasms/*etiology
Aged ; Case-Control Studies ; Female ; Gender Identity ; Humans ; Middle Aged ; Ovarian Neoplasms/pathology ; Risk Factors
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Grant Information:: K07 CA080668 United States CA NCI NIH HHS; R01 CA095023 United States CA NCI NIH HHS
Contributed Indexing:: Keywords: Case-control study; Epithelial ovarian cancer; Gender of offspring
Entry Date(s):: Date Created: 20191214 Date Completed: 20200818 Latest Revision: 20210201
Update Code:: 20240105
PubMed Central ID:: PMC6983354
DOI:: 10.1016/j.canep.2019.101646
PMID:: 31835157
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Objective: To examine the association between gender of offspring and epithelial ovarian cancer (EOC).
Methods: We compared gender of offspring between 664 incident EOC cases and 1531 controls participating in a population-based study conducted in Pennsylvania, Ohio, and New York from 2003-2008. Multivariable unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) adjusting for potential confounders.
Results: Bearing a male offspring was associated with an 8 % lower EOC risk; bearing all boys was associated with an 11 % lower risk. Compared to bearing all girls, bearing all boys was associated with a 14 % decrease risk. Increasing number of male offspring increased the protective effect (adjusted-OR: 0.92, 0.91, 0.84, for 1, 2, and 3+ boys compared to all girls). Results where similar when limiting cases to invasive disease and to the high-grade serous histotype.
Conclusion: Fetal sex, which influences maternal hormonal milieu, may impact EOC risk.
Competing Interests: Declaration of Competing Interest The authors report no conflict of interest.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)

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