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Tytuł pozycji:

Vitamin K role in mineral and bone disorder of chronic kidney disease.

Tytuł:
Vitamin K role in mineral and bone disorder of chronic kidney disease.
Autorzy:
de Oliveira RB; Division of Nephrology, Department of Internal Medicine, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil; Laboratory for Evaluation of Mineral and Bone Disorders in Nephrology (LEMON), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
Stinghen AEM; Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, Brazil.
Massy ZA; Ambroise Paré University Hospital, Nephrology Division, APHP, UVSQ, France; INSERM U1018 Eq5, UVSQ, University Paris Saclay, Villejuif, France. Electronic address: .
Źródło:
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2020 Mar; Vol. 502, pp. 66-72. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Original Publication: Amsterdam, Elsevier.
MeSH Terms:
Chronic Kidney Disease-Mineral and Bone Disorder/*metabolism
Vitamin K/*metabolism
Vitamin K Deficiency/*metabolism
Chronic Kidney Disease-Mineral and Bone Disorder/drug therapy ; Humans ; Molecular Structure ; Vitamin K/administration & dosage ; Vitamin K/therapeutic use ; Vitamin K Deficiency/drug therapy
Contributed Indexing:
Keywords: Bone mineralization; Chronic kidney disease; Vascular calcification; Vitamin K
Substance Nomenclature:
12001-79-5 (Vitamin K)
Entry Date(s):
Date Created: 20191215 Date Completed: 20201001 Latest Revision: 20201001
Update Code:
20240105
DOI:
10.1016/j.cca.2019.11.040
PMID:
31836502
Czasopismo naukowe
Vitamin K is a key cofactor for the activation of proteins involved in blood coagulation, apoptosis, bone mineralization regulation, and vessel health. Scientific evidence shows an important role of activated osteocalcin and matrix-Gla protein in bone and vessels, markedly affected along the course of chronic kidney disease (CKD). In fact, CKD corresponds to an unique condition of vitamin K deficiency caused by dietary restriction, intestinal dysfunction, and impaired vitamin K recycling. Clinical data suggest that vitamin K status can be modulated and this prompts us to speculate whether patients with CKD might benefit from vitamin K supplementation. However, as important as whether the improvement in vitamin K status would be able to result in better bone quality, less vascular calcification, and lower mortality rates, several issues need to be clarified. These include better standardized methods for measuring vitamin K levels, and definition of the optimal concentration range for supplementation in different subgroups. Here, we review the literature data concerning the impact of vitamin K deficiency and supplementation on CKD-associated mineral and bone disorders (CKD-MBD). We present and discuss the available evidence from basic science and clinical studies, and highlight perspectives for further research.
Competing Interests: Declarations of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2019 Elsevier B.V. All rights reserved.)

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