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Tytuł:
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Dogs are reservoir hosts for possible transmission of human strongyloidiasis in Thailand: molecular identification and genetic diversity of causative parasite species.
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Autorzy:
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Sanpool O; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.; Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.
Intapan PM; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.; Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.
Rodpai R; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.; Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.
Laoraksawong P; School of Health Science, Sukhothai Thammathirat Open University Pakkret, Nonthaburi11120, Thailand.
Sadaow L; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.; Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.
Tourtip S; Faculty of Medicine, Mahasarakham University, Maha Sarakham44000, Thailand.
Piratae S; One Health Research Unit, Faculty of Veterinary Sciences, Mahasarakham University, Maha Sarakham44000, Thailand.
Maleewong W; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.; Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.
Thanchomnang T; Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen40002, Thailand.; Faculty of Medicine, Mahasarakham University, Maha Sarakham44000, Thailand.
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Źródło:
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Journal of helminthology [J Helminthol] 2019 Dec 17; Vol. 94, pp. e110. Date of Electronic Publication: 2019 Dec 17.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: London : London School Of Hygiene And Tropical Medicine
Original Publication: London [etc.]
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MeSH Terms:
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Genetic Variation*
Disease Reservoirs/*veterinary
Dog Diseases/*parasitology
Dog Diseases/*transmission
Strongyloidiasis/*transmission
Zoonoses/*transmission
Animals ; Cyclooxygenase 1/genetics ; DNA, Helminth/genetics ; Disease Reservoirs/parasitology ; Dogs/parasitology ; Family Characteristics ; Feces/parasitology ; Haplotypes ; Humans ; Male ; Pets/parasitology ; Phylogeny ; RNA, Ribosomal, 18S/genetics ; Rural Population ; Strongyloides stercoralis/genetics ; Strongyloidiasis/epidemiology ; Strongyloidiasis/parasitology ; Thailand/epidemiology ; Zoonoses/parasitology
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Contributed Indexing:
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Keywords: Strongyloides stercoralis; cat; dog; human; molecular identification; zoonotic transmission
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Substance Nomenclature:
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0 (DNA, Helminth)
0 (RNA, Ribosomal, 18S)
EC 1.14.99.1 (Cyclooxygenase 1)
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Entry Date(s):
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Date Created: 20191218 Date Completed: 20200417 Latest Revision: 20200417
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Update Code:
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20240105
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DOI:
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10.1017/S0022149X1900107X
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PMID:
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31843028
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Human strongyloidiasis is a deleterious gastrointestinal disease mainly caused by Strongyloides stercoralis infection. We aimed to study the possible transmission of S. stercoralis between humans and pet animals. We isolated Strongyloides from humans and domestic dogs in the same rural community in north-east Thailand and compared the nucleotide sequences of derived worms using portions of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and 18S ribosomal RNA (18S rRNA) genes. Twenty-eight sequences from the 18S rRNA gene were obtained from worms derived from humans (n = 23) and dogs (n = 5), and were identical with S. stercoralis sequences (from Thailand, Cambodia, Lao PDR and Myanmar) published in the GenBank database. The 28 cox1 sequences from humans and dogs showed high similarity to each other. The available published cox1 sequences (n = 150), in combination with our 28 sequences, represented 68 haplotypes distributed among four clusters. The 28 samples from the present study represented eight haplotypes including four new haplotypes. Dogs and humans shared the same haplotypes, suggesting the possibility of zoonotic transmission from pet dogs to humans. This is of concern since dogs and humans live in close association with each other.
