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Tytuł:
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Recent Advancements and Applications of Human Immune System Mice in Preclinical Immuno-Oncology.
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Autorzy:
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Curran M; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Campus, Cambridge, United Kingdom.
Mairesse M; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Matas-Céspedes A; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Campus, Cambridge, United Kingdom.
Bareham B; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Campus, Cambridge, United Kingdom.
Pellegrini G; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Liaunardy A; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Powell E; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Campus, Cambridge, United Kingdom.
Sargeant R; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Cuomo E; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Stebbings R; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Betts CJ; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom.
Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Campus, Cambridge, United Kingdom.
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Źródło:
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Toxicologic pathology [Toxicol Pathol] 2020 Feb; Vol. 48 (2), pp. 302-316. Date of Electronic Publication: 2019 Dec 18.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: Thousand Oaks, Calif. : Sage Publications
Original Publication: [Newark, Del,] Society of Pharmacological and Environmental Pathologists.
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MeSH Terms:
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Disease Models, Animal*
Immune System*
Immunologic Techniques*
Medical Oncology/*methods
Allergy and Immunology ; Animals ; Humans ; Immunologic Factors/pharmacology ; Mice
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Contributed Indexing:
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Keywords: alternative models in toxicology; animal models; cancer; humanized mice; immune system; immunopathology; immunotoxicity; preclinical safety-assessment/risk management
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Substance Nomenclature:
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0 (Immunologic Factors)
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Entry Date(s):
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Date Created: 20191219 Date Completed: 20210604 Latest Revision: 20210604
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Update Code:
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20240105
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DOI:
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10.1177/0192623319886304
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PMID:
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31847725
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Significant advances in immunotherapies have resulted in the increasing need of predictive preclinical models to improve immunotherapeutic drug development, treatment combination, and to prevent or minimize toxicity in clinical trials. Immunodeficient mice reconstituted with human immune system (HIS), termed humanized mice or HIS mice, permit detailed analysis of human immune biology, development, and function. Although this model constitutes a great translational model, some aspects need to be improved as the incomplete engraftment of immune cells, graft versus host disease and the lack of human cytokines and growth factors. In this review, we discuss current HIS platforms, their pathology, and recent advances in their development to improve the quality of human immune cell reconstitution. We also highlight new technologies that can be used to better understand these models and how improved characterization is needed for their application in immuno-oncology safety, efficacy, and new modalities therapy development.