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Tytuł:
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Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis.
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Autorzy:
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King RL; Division of Hematopathology, Mayo Clinic, Rochester, MN, USA.
Goodlad JR; Department of Pathology, Queen Elizabeth University Hospital, Glasgow, UK.
Calaminici M; Department of Cellular Pathology, SIHMDS, Barts Health NHS Trust and Centre for Haemato-Oncology, Barts Cancer Institute, London, UK.
Dotlic S; Department of Pathology and Cytology, University Hospital Centre Zagreb, University of Zagreb Medical School, Zagreb, Croatia.
Montes-Moreno S; Anatomic Pathology Service and Translational Hematopathology Lab, Hospital Universitario Marques de Valdecilla/IDIVAL, Santander, Spain.
Oschlies I; Department of Pathology, Hematopathology Section and Lymphnode Registry, University Hospitals Schleswig-Holstein, Christian-Albrecht-University, Kiel, Germany.
Ponzoni M; Ateneo Vita-Salute San Raffaele and Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy.
Traverse-Glehen A; Department of Hematopathology, Hospices Civils de Lyon/Université Lyon 1, Lyon, France.
Ott G; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
Ferry JA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. .
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Źródło:
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Virchows Archiv : an international journal of pathology [Virchows Arch] 2020 May; Vol. 476 (5), pp. 647-665. Date of Electronic Publication: 2019 Dec 20.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Berlin ; New York : Springer International, c1994-
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MeSH Terms:
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Immune Privilege*
Central Nervous System Neoplasms/*diagnosis
Lymphoma/*diagnosis
Lymphoma, Large B-Cell, Diffuse/*diagnosis
Lymphoma, Large-Cell, Anaplastic/*diagnosis
Testicular Neoplasms/*diagnosis
Breast Implants/adverse effects ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/immunology ; Central Nervous System Neoplasms/pathology ; Education ; Female ; Humans ; Lymphoma/genetics ; Lymphoma/immunology ; Lymphoma/pathology ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Large-Cell, Anaplastic/immunology ; Lymphoma, Large-Cell, Anaplastic/pathology ; Male ; Signal Transduction ; Testicular Neoplasms/genetics ; Testicular Neoplasms/immunology ; Testicular Neoplasms/pathology
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Contributed Indexing:
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Keywords: Breast implant–associated anaplastic large cell lymphoma; Central nervous system lymphoma; Diffuse large B cell lymphoma associated with chronic inflammation; Fibrin-associated diffuse large B cell lymphoma; Immune privilege; Testicular lymphoma
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Entry Date(s):
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Date Created: 20191222 Date Completed: 20200601 Latest Revision: 20200601
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Update Code:
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20240105
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DOI:
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10.1007/s00428-019-02698-3
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PMID:
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31863183
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Session 2 of the 2018 European Association of Hematopathology/Society for Hematopathology Workshop focused on lymphomas arising in immune-privileged sites: both lymphomas arising in the traditionally described "immune sanctuary" sites of the central nervous system (CNS) and testes, as well as those arising at sites of local immune privilege. Primary CNS large B cell lymphoma and primary testicular large B cell lymphoma were discussed, and the biology of these unique tumors was highlighted by several cases showing the classic mutation profile including MYD88 L265P and CD79B. The tendency of these tumors to involve both the CNS and testis was also reinforced by several cases. Four cases of low-grade B cell lymphomas (LGBCL) of the CNS were discussed. Two were classic Bing-Neel syndrome associated with LPL, and two were LGBCL with plasmacytic differentiation and amyloid deposition without systemic disease. Rare examples of systemic T and NK cell lymphomas involving the CNS were also discussed. Several cases of breast implant-associated anaplastic large cell lymphoma (BI-ALCL) were submitted showing the typical clinicopathologic features. These cases were discussed along with a case with analogous features arising in a patient with a gastric band implant, as well as large B cell lymphomas arising alongside foreign materials. Finally, large B cell lymphomas arising in effusions or localized sites of chronic inflammation (fibrin-associated diffuse large B cell lymphoma [DLBCL] and DLBCL associated with chronic inflammation) were described. The pathogenesis of all of these lymphomas is believed to be related to decreased immune surveillance, either innate to the physiology of the organ or acquired at a local site.