Postmortem Diagnosis of Fatal Hypothermia by Fourier Transform Infrared Spectroscopic Analysis of Edema Fluid in Formalin-Fixed, Paraffin-Embedded Lung Tissues.

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Abstrakt

Tytuł:: Postmortem Diagnosis of Fatal Hypothermia by Fourier Transform Infrared Spectroscopic Analysis of Edema Fluid in Formalin-Fixed, Paraffin-Embedded Lung Tissues.
Autorzy:: Lin H; Department of Forensic Pathology, Xi'an Jiaotong University, Xi'an, 710061, China.; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, 200063, China.
Guo X; Forensic Medicine School, China Medical University, Shenyang, 110122, China.
Luo Y; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, 200063, China.
Chen Y; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, 200063, China.
Zhao R; Forensic Medicine School, China Medical University, Shenyang, 110122, China.
Guan D; Forensic Medicine School, China Medical University, Shenyang, 110122, China.
Wang Z; Department of Forensic Pathology, Xi'an Jiaotong University, Xi'an, 710061, China.
Huang P; Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, 200063, China.
Źródło:: Journal of forensic sciences [J Forensic Sci] 2020 May; Vol. 65 (3), pp. 846-854. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2006- : Malden, MA : Blackwell Pub.
Original Publication: [Chicago, Ill.] : Callaghan and Co., 1956-
MeSH Terms:: Spectroscopy, Fourier Transform Infrared*
Hypothermia/*diagnosis
Pulmonary Edema/*metabolism
Algorithms ; Chemistry Techniques, Analytical ; Discriminant Analysis ; Formaldehyde ; Humans ; Least-Squares Analysis ; Lung/pathology ; Paraffin Embedding ; Principal Component Analysis ; Protein Conformation, beta-Strand
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Grant Information:: 2016YFC0800702 National Key R&D Program of China; 81671869 National Natural Science Foundation of China; 81722027 National Natural Science Foundation of China; 81730056 National Natural Science Foundation of China; 17DZ2273200 Science and Technology Committee of Shanghai Municipality; 19DZ2292700 Science and Technology Committee of Shanghai Municipality
Contributed Indexing:: Keywords: Fourier transform infrared microspectroscopy; chemometrics; fatal hypothermia; partial least-squares discriminant analysis; postmortem diagnosis; pulmonary edema fluid
Substance Nomenclature:: 1HG84L3525 (Formaldehyde)
Entry Date(s):: Date Created: 20191224 Date Completed: 20210119 Latest Revision: 20210119
Update Code:: 20240105
DOI:: 10.1111/1556-4029.14260
PMID:: 31868923
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The goal of this study was to investigate whether pulmonary edema could become a specific diagnostic marker for fatal hypothermia using Fourier transform infrared (FTIR) spectroscopy in combination with chemometrics. The spectral profile analysis indicated that hypothermia fatalities associated with pulmonary edema fluid contained more β-sheet protein conformational structures than the control causes of death, which included sudden cardiac death, brain injury, cerebrovascular disease, mechanical asphyxiation, intoxication, and drowning. Subsequently, the results of principal component analysis (PCA) further revealed that the content of β-sheet protein conformational structures in the pulmonary edema fluid was the main discriminatory marker between fatal hypothermia and the other causes of death. Ultimately, a robust postmortem diagnostic model for fatal hypothermia using a partial least-squares discriminant analysis (PLS-DA) algorithm was constructed. Pulmonary edema fluid spectra collected from eight new forensic autopsy cases that did not participate in the construction of the diagnostic model were predicted using the model. The results showed the causes of death of all these eight cases were correctly classified. In conclusion, this preliminary study demonstrates that FTIR spectroscopy in combination with chemometrics could be a promising approach for the postmortem diagnosis of fatal hypothermia.
(© 2019 American Academy of Forensic Sciences.)

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