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Tytuł:
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IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis.
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Autorzy:
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Solomon JJ; Interstitial Lung Disease Program & Autoimmune Lung Center, National Jewish Health, Denver, CO. Electronic address: .
Matson S; Division of Pulmonary and Critical Care Medicine, University of Colorado Denver, Aurora, CO.
Kelmenson LB; Division of Rheumatology, University of Colorado Denver, Aurora, CO.
Chung JH; Department of Radiology, University of Chicago, Chicago, IL.
Hobbs SB; Department of Radiology, University of Kentucky, Lexington, KY.
Rosas IO; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
Dellaripa PF; Division of Rheumatology, Brigham and Women's Hospital, Boston, MA.
Doyle TJ; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
Poli S; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
Esposito AJ; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
Visser A; Division of Rheumatology, University of Colorado Denver, Aurora, CO.
Marin AI; Division of Rheumatology, University of Colorado Denver, Aurora, CO.
Amigues I; Division of Rheumatology, National Jewish Health, Denver, CO.
Fernández Pérez ER; Interstitial Lung Disease Program & Autoimmune Lung Center, National Jewish Health, Denver, CO.
Brown KK; Interstitial Lung Disease Program & Autoimmune Lung Center, National Jewish Health, Denver, CO.
Mahler M; Inova Diagnostics, San Diego, CA.
Heinz D; Department of Pathology, National Jewish Health, Denver, CO.
Cool C; Department of Pathology, National Jewish Health, Denver, CO; Department of Pathology, University of Colorado Denver, Aurora, CO.
Deane KD; Division of Rheumatology, University of Colorado Denver, Aurora, CO.
Swigris JJ; Interstitial Lung Disease Program & Autoimmune Lung Center, National Jewish Health, Denver, CO.
Demoruelle MK; Division of Rheumatology, University of Colorado Denver, Aurora, CO.
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Źródło:
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Chest [Chest] 2020 Jun; Vol. 157 (6), pp. 1513-1521. Date of Electronic Publication: 2019 Dec 23.
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Typ publikacji:
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Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2016- : New York : Elsevier
Original Publication: Chicago : American College of Chest Physicians
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MeSH Terms:
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Autoantibodies/*blood
Idiopathic Pulmonary Fibrosis/*immunology
Immunoglobulin A/*blood
Aged ; Autoantibodies/immunology ; Biomarkers/blood ; Female ; Humans ; Idiopathic Pulmonary Fibrosis/blood ; Immunoglobulin A/immunology ; Male ; Middle Aged
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References:
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Grant Information:
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R03 HL148484 United States HL NHLBI NIH HHS; K23 HL119558 United States HL NHLBI NIH HHS; R56 AI103023 United States AI NIAID NIH HHS; L30 HL149048 United States HL NHLBI NIH HHS; K23 AR066712 United States AR NIAMS NIH HHS
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Contributed Indexing:
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Keywords: immunology (lung); interstitial lung disease; rheumatoid arthritis
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Substance Nomenclature:
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0 (Autoantibodies)
0 (Biomarkers)
0 (Immunoglobulin A)
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Entry Date(s):
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Date Created: 20191227 Date Completed: 20210517 Latest Revision: 20220912
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Update Code:
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20240105
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PubMed Central ID:
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PMC7268435
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DOI:
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10.1016/j.chest.2019.12.005
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PMID:
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31877269
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Background: The etiology of idiopathic pulmonary fibrosis (IPF) is unknown. Because it shares genetic, histopathologic, and radiographic features with the fibrosing interstitial lung disease seen in rheumatoid arthritis (RA), the goal of this study was to investigate RA-related autoantibodies in IPF.
Methods: The study included patients with IPF from two separate cohorts at National Jewish Health and Brigham Women's Hospital (n = 181), general population control subjects (n = 160), and control subjects with disease (n = 86 [40 with RA-usual interstitial pneumonia and 46 with hypersensitivity pneumonitis]). Serum was tested for RA-associated antibodies (including IgG and IgA) to citrullinated protein antigens (ACPA). Lung tissue in 11 patients with IPF was examined for ectopic lymphoid aggregates.
Results: An increased prevalence of ACPA positivity was found in two separate IPF cohorts. In particular, positivity for IgA-ACPA was increased in these two IPF cohorts compared with general population control subjects (21.3% and 24.8% vs 5.6%; P < .01). Patients with IPF were more likely to be IgA-ACPA-positive than IgG-ACPA-positive (23.2% vs 8.3%; P < .01), whereas patients with RA were more likely to be IgG-ACPA-positive than IgA-ACPA-positive (72.5% vs 52.5%; P = .04). There was a strong correlation between IgA-ACPA level and the number of ectopic lymphoid aggregates on lung histologic examination in IPF (r = 0.72; P = .01).
Conclusions: In this study, IgA-ACPA was elevated in patients with IPF and correlated with lymphoid aggregates in the lung, supporting the theory that IgA-ACPA may play a role in lung disease pathogenesis in a subset of individuals with IPF. Future studies are needed to determine whether this subset of ACPA-positive patients with IPF is distinct from patients with IPF but without antibodies.
(Copyright © 2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)
Comment in: Chest. 2020 Oct;158(4):1777-1778. (PMID: 33036087)
Comment in: Chest. 2020 Oct;158(4):1778-1779. (PMID: 33036088)
