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Tytuł pozycji:

The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance.

Tytuł:
The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance.
Autorzy:
Womersley JS; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa. .; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Francie van Zijl Drive, Tygerberg, 7505, South Africa. .
Clauss LB; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa.; Joint Master in Neuroscience, Faculty of Life Sciences, University of Strasbourg, Strasbourg, France.
Varathan O; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa.
Engelbrecht S; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa.; National Health Laboratory Services (NHLS), Tygerberg Coastal, Tygerberg, Western Cape Region, South Africa.
Hemmings SMJ; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Francie van Zijl Drive, Tygerberg, 7505, South Africa.
Seedat S; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Francie van Zijl Drive, Tygerberg, 7505, South Africa.
Spies G; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa.; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Francie van Zijl Drive, Tygerberg, 7505, South Africa.
Źródło:
BMC research notes [BMC Res Notes] 2019 Dec 27; Vol. 12 (1), pp. 828. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: London : Biomed Central, 2008.
MeSH Terms:
Adverse Childhood Experiences*
Apolipoproteins E/*genetics
HIV Infections/*psychology
Neurocognitive Disorders/*etiology
vpr Gene Products, Human Immunodeficiency Virus/*blood
Adult ; Apolipoproteins E/blood ; Child ; Cognition/physiology ; Cohort Studies ; Demography ; Female ; Follow-Up Studies ; Genotype ; HIV Infections/complications ; Humans ; Neurocognitive Disorders/genetics ; Neurocognitive Disorders/psychology ; Neurocognitive Disorders/virology ; Neuropsychological Tests ; South Africa ; Surveys and Questionnaires
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Grant Information:
P30 AI036214 United States AI NIAID NIH HHS; UL1 TR001442 United States TR NCATS NIH HHS
Contributed Indexing:
Keywords: Apolipoprotein E; Childhood trauma; HIV-associated neurocognitive disorders; Viral protein R
Substance Nomenclature:
0 (Apolipoproteins E)
0 (vpr Gene Products, Human Immunodeficiency Virus)
0 (vpr protein, Human immunodeficiency virus 1)
Entry Date(s):
Date Created: 20191229 Date Completed: 20200608 Latest Revision: 20240124
Update Code:
20240124
PubMed Central ID:
PMC6935155
DOI:
10.1186/s13104-019-4869-9
PMID:
31881924
Czasopismo naukowe
Objective: Gene-environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance.
Results: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).
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