Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy.

Tytuł:: Specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils, are associated with IgA nephropathy.
Autorzy:: Ito S; Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Saitama, Japan. .
Misaki T; Division of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.; Department of Nursing, Faculty of Nursing, Seirei Christopher University, Hamamatsu, Shizuoka, Japan.
Naka S; Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Wato K; Department of Pediatric Dentistry, Division of Oral infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Nagasawa Y; Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Nomura R; Department of Pediatric Dentistry, Division of Oral infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Otsugu M; Department of Pediatric Dentistry, Division of Oral infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Matsumoto-Nakano M; Department of Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan.
Nakano K; Department of Pediatric Dentistry, Division of Oral infection and Disease Control, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Kumagai H; Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Oshima N; Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Źródło:: Scientific reports [Sci Rep] 2019 Dec 27; Vol. 9 (1), pp. 20130. Date of Electronic Publication: 2019 Dec 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Disease Susceptibility*/immunology
Glomerulonephritis, IGA/*etiology
Palatine Tonsil/*immunology
Palatine Tonsil/*microbiology
Streptococcus mutans/*immunology
Adult ; Biomarkers ; Biopsy ; Female ; Glomerulonephritis, IGA/diagnosis ; Glomerulonephritis, IGA/metabolism ; Humans ; Male ; Middle Aged ; Palatine Tonsil/pathology ; Streptococcal Infections/complications ; Streptococcal Infections/immunology ; Streptococcal Infections/microbiology ; Tonsillitis/complications ; Tonsillitis/immunology ; Tonsillitis/microbiology ; Tonsillitis/pathology
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Substance Nomenclature:: 0 (Biomarkers)
Entry Date(s):: Date Created: 20191229 Date Completed: 20201116 Latest Revision: 20210110
Update Code:: 20240104
PubMed Central ID:: PMC6934739
DOI:: 10.1038/s41598-019-56679-2
PMID:: 31882880
: Czasopismo naukowe

Pełny tekst

Streptococcus mutans is known to be a major causative agent of dental caries, and strains expressing the cell surface collagen-binding Cnm protein contribute to the development of several systemic diseases. A relationship between tonsillar immunity and glomerulonephritis has been recognized in IgA nephropathy (IgAN), and specific pathogens may have effects on tonsillar immunity (mucosal immunity). Here, we present findings showing a relationship between the presence of Cnm-positive S. mutans strains in the tonsils of IgAN patients and IgAN condition/pathogenesis. Analyses of tonsillar specimens obtained from patients with IgAN (n = 61) and chronic tonsillitis (controls; n = 40) showed that the Cnm protein-positive rate was significantly higher in IgAN patients. Among IgAN patients, the tonsillar Cnm-positive group (n = 15) had a significantly higher proportion of patients with high urinary protein (>1.5 g/gCr) and lower serum albumin level than the Cnm-negative group (n = 46). Additionally, Cnm protein and CD68, a common human macrophage marker, were shown to be merged in the tonsils of IgAN patients. These findings suggest that Cnm-positive S. mutans strains in the tonsils may be associated with severe IgAN.

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