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Tytuł pozycji:

Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia.

Tytuł:
Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia.
Autorzy:
Zeleke A; Department of Pharmacy, Wollo University, Dessie, Ethiopia. .
Misiker B; Department of Pharmacy, Wollo University, Dessie, Ethiopia.
Yesuf TA; Department of Pharmacy, Wollo University, Dessie, Ethiopia.
Źródło:
BMC research notes [BMC Res Notes] 2020 Jan 02; Vol. 13 (1), pp. 2. Date of Electronic Publication: 2020 Jan 02.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: London : Biomed Central, 2008.
MeSH Terms:
Referral and Consultation*
Chemical and Drug Induced Liver Injury/*complications
Coinfection/*complications
HIV Infections/*complications
Tuberculosis/*complications
Adolescent ; Adult ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Young Adult
References:
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Cad Saude Publica. 2012 Apr;28(4):698-708. (PMID: 22488315)
PLoS One. 2011;6(7):e21836. (PMID: 21750735)
PLoS One. 2013 May 16;8(5):e64622. (PMID: 23696901)
Am J Respir Crit Care Med. 2001 Oct 1;164(7):1112-3. (PMID: 11673194)
Int J Mycobacteriol. 2016 Dec;5(4):482-488. (PMID: 27931691)
PLoS One. 2008 Mar 19;3(3):e1809. (PMID: 18350147)
MMWR Recomm Rep. 2009 Apr 10;58(RR-4):1-207; quiz CE1-4. (PMID: 19357635)
Clin Chest Med. 2005 Jun;26(2):283-94, vi-vii. (PMID: 15837111)
Contributed Indexing:
Keywords: Hepatotoxicity; Human immunodeficiency virus; Tuberculosis
Entry Date(s):
Date Created: 20200104 Date Completed: 20200924 Latest Revision: 20200924
Update Code:
20240104
PubMed Central ID:
PMC6941240
DOI:
10.1186/s13104-019-4872-1
PMID:
31898556
Czasopismo naukowe
Objectives: Anti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence and associated factors of drug-induced hepatotoxicity among tuberculosis and human immunodeficiency virus co-infected patients in Dessie referral hospital northeast Ethiopia.
Results: In this cross-sectional study 84 patients were enrolled retrospectively. Data from September 1/2015 to August 30/2018 were extracted from March 1/2019 to April 1/2019. Association between dependent and independent variables was determined using the odds ratio and a P value of < 0.05 was considered as statistical significance. Out of 84 patients, 17 patients developed drug-induced hepatotoxicity which makes the prevalence of drug-induced hepatotoxicity 20.2%. The result revealed that the presence of disseminated or extrapulmonary tuberculosis [(AOR: 7.728, 95% CI (1.516-39.404)] and/or body mass index less than 18.5 kg/m 2 [(AOR = 5.593, 95% CI (1.180-26.519)] were a risk factor for drug-induced hepatotoxicity. Tuberculosis and human immunodeficiency virus co-infected patients with extra- pulmonary tuberculosis and/or body mass index less than 18.5 kg/m2 should be closely followed and supervised for the development of hepatotoxicity.
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