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Tytuł:
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Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia.
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Autorzy:
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Zeleke A; Department of Pharmacy, Wollo University, Dessie, Ethiopia. .
Misiker B; Department of Pharmacy, Wollo University, Dessie, Ethiopia.
Yesuf TA; Department of Pharmacy, Wollo University, Dessie, Ethiopia.
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Źródło:
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BMC research notes [BMC Res Notes] 2020 Jan 02; Vol. 13 (1), pp. 2. Date of Electronic Publication: 2020 Jan 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: London : Biomed Central, 2008.
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MeSH Terms:
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Referral and Consultation*
Chemical and Drug Induced Liver Injury/*complications
Coinfection/*complications
HIV Infections/*complications
Tuberculosis/*complications
Adolescent ; Adult ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Young Adult
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References:
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N Engl J Med. 2003 Jul 31;349(5):474-85. (PMID: 12890847)
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PLoS One. 2011;6(7):e21836. (PMID: 21750735)
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Clin Chest Med. 2005 Jun;26(2):283-94, vi-vii. (PMID: 15837111)
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Contributed Indexing:
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Keywords: Hepatotoxicity; Human immunodeficiency virus; Tuberculosis
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Entry Date(s):
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Date Created: 20200104 Date Completed: 20200924 Latest Revision: 20200924
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Update Code:
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20240104
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PubMed Central ID:
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PMC6941240
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DOI:
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10.1186/s13104-019-4872-1
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PMID:
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31898556
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Objectives: Anti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence and associated factors of drug-induced hepatotoxicity among tuberculosis and human immunodeficiency virus co-infected patients in Dessie referral hospital northeast Ethiopia.
Results: In this cross-sectional study 84 patients were enrolled retrospectively. Data from September 1/2015 to August 30/2018 were extracted from March 1/2019 to April 1/2019. Association between dependent and independent variables was determined using the odds ratio and a P value of < 0.05 was considered as statistical significance. Out of 84 patients, 17 patients developed drug-induced hepatotoxicity which makes the prevalence of drug-induced hepatotoxicity 20.2%. The result revealed that the presence of disseminated or extrapulmonary tuberculosis [(AOR: 7.728, 95% CI (1.516-39.404)] and/or body mass index less than 18.5 kg/m 2 [(AOR = 5.593, 95% CI (1.180-26.519)] were a risk factor for drug-induced hepatotoxicity. Tuberculosis and human immunodeficiency virus co-infected patients with extra- pulmonary tuberculosis and/or body mass index less than 18.5 kg/m2 should be closely followed and supervised for the development of hepatotoxicity.
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