Structural abnormality in schizophrenia versus bipolar disorder: A whole brain cortical thickness, surface area, volume and gyrification analyses.

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Tytuł:: Structural abnormality in schizophrenia versus bipolar disorder: A whole brain cortical thickness, surface area, volume and gyrification analyses.
Autorzy:: Madre M; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain. Electronic address: .
Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address: .
Fuentes-Claramonte P; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Alonso-Lana S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Salgado-Pineda P; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Guerrero-Pedraza A; Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain.
Moro N; Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain.
Bosque C; Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain.
Gomar JJ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; The Litwin-Zucker Alzheimer's Research Center, NY, USA.
Ortíz-Gil J; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Hospital General de Granollers, Granollers, Catalonia, Spain.
Goikolea JM; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Bonnin CM; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Vieta E; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Bipolar Disorder Program, Institute of Neuroscience, Hospital Clínic, University of Barcelona, IDIBAPS, Barcelona, Spain.
Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Maristany T; Diagnostic Imaging Department, Fundació de Recerca Hospital Sant Joan de Déu, Barcelona, Spain.
McKenna PJ; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Źródło:: NeuroImage. Clinical [Neuroimage Clin] 2020; Vol. 25, pp. 102131. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: [Amsterdam] : Elsevier
MeSH Terms:: Brain Cortical Thickness*
Bipolar Disorder/*pathology
Cerebral Cortex/*pathology
Schizophrenia/*pathology
Adult ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged
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Contributed Indexing:: Keywords: Bipolar disorder; Cortical thickness; Gyrification index; Neuroimaging; Schizophrenia; Surface area; Surface-based morphometry
Entry Date(s):: Date Created: 20200109 Date Completed: 20201214 Latest Revision: 20231113
Update Code:: 20240105
PubMed Central ID:: PMC6948361
DOI:: 10.1016/j.nicl.2019.102131
PMID:: 31911343
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Objectives: The profiles of cortical abnormalities in schizophrenia and bipolar disorder, and how far they resemble each other, have only been studied to a limited extent. The aim of this study was to identify and compare the changes in cortical morphology associated with these pathologies.
Methods: A total of 384 subjects, including 128 patients with schizophrenia, 128 patients with bipolar disorder and 127 sex-age-matched healthy subjects, were examined using cortical surface-based morphology. Four cortical structural measures were studied: cortical volume (CV), cortical thickness (CT), surface area (SA) and gyrification index (GI). Group comparisons for each separate cortical measure were conducted.
Results: At a threshold of P = 0.05 corrected, both patient groups showed significant widespread CV and CT reductions in similar areas compared to healthy subjects. However, the changes in schizophrenia were more pronounced. While CV decrease in bipolar disorder was exclusively explained by cortical thinning, in schizophrenia it was driven by changes in CT and partially by SA. Reduced GI was only found in schizophrenia. The direct comparison between both disorders showed significant reductions in all measures in patients with schizophrenia.
Conclusions: Cortical volume and cortical thickness deficits are shared between patients with schizophrenia and bipolar disorder, suggesting that both pathologies may be affected by similar environmental and neurodegenerative factors. However, the exclusive alteration in schizophrenia of metrics related to the geometry and curvature of the brain cortical surface (SA, GI) suggests that this group is influenced by additional neurodevelopmental and genetic factors.
Competing Interests: Declaration of Competing of Interest All authors declare that they have no conflicts of interest.
(Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.)

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