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Tytuł:
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Block .
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Autorzy:
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Lei Z; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.; Institute of Smart Fiber Materials, Zhejiang Sci-Tech University, Hangzhou, China.
Tang Q; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.
Ju Y; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.
Lin Y; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.
Bai X; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.
Luo H; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.; Institute of Smart Fiber Materials, Zhejiang Sci-Tech University, Hangzhou, China.
Tong Z; College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China.; Institute of Smart Fiber Materials, Zhejiang Sci-Tech University, Hangzhou, China.
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Źródło:
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Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2020 Apr; Vol. 31 (6), pp. 695-711. Date of Electronic Publication: 2020 Jan 20.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2012- : Abingdon, Oxon : Taylor and Francis
Original Publication: Utrecht, The Netherlands : VSP, c1989-
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MeSH Terms:
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Drug Carriers/*chemistry
Imidazoles/*chemistry
Metal-Organic Frameworks/*chemistry
Nanocomposites/*chemistry
Polymers/*chemistry
Delayed-Action Preparations ; Doxorubicin/chemistry ; Drug Carriers/toxicity ; Humans ; Hydrogen-Ion Concentration ; MCF-7 Cells ; Micelles ; Nanocomposites/toxicity ; Water/chemistry
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Contributed Indexing:
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Keywords: pH-responsiveness; Core-shell nanoparticles; block copolymer; drug delivery; zeolitic imidazolate frameworks-8
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Substance Nomenclature:
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0 (Delayed-Action Preparations)
0 (Drug Carriers)
0 (Imidazoles)
0 (Metal-Organic Frameworks)
0 (Micelles)
0 (Polymers)
0 (ZIF-8 metal-organic framework)
059QF0KO0R (Water)
80168379AG (Doxorubicin)
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Entry Date(s):
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Date Created: 20200109 Date Completed: 20210707 Latest Revision: 20210707
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Update Code:
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20240105
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DOI:
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10.1080/09205063.2020.1713451
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PMID:
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31914358
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Developing the hybrid nanosystems for controlled drug release is still a challenging task. In this work, pH-responsive core-shell nanocomposites have been prepared by the growth of zeolitic imidazolate framework-8 (ZIF-8) on the surface of polymeric aggregates self-assembled from poly(ε-caprolactone)- block -poly ( quaternized vinylbenzyl chloride/bipyridine) (PCL- b - q (PVBC/BPy), BCP for short) in water. The core of the micelles or the inner cavity of vesicles serves as the drug storage reservoir for the doxorubicin hydrochloride (DOX) and the ZIF-8 shells act as the gatekeepers to prevent drug premature release at physiological environment. Upon pH stimulus, the core-shell nanocomposites (BCP@ZIF-8) show a retarded drug release behavior compared with DOX-loaded polymeric aggregates counterparts (without the shell of ZIF-8). Moreover, the as-prepared nanocomposites perform good biocompatibility towards MCF-7 cell. Meanwhile, the DOX-loaded BCP@ZIF-8 nanocomposites present lower cytotoxicity compared with DOX-loaded BCP and free DOX. The confocal microscopy study shows the core-shell nanocomposites could be efficiently internalized by cancer cells, and the loaded DOX could be successfully released under acidic intracellular environment. The above result shows that the core-shell nanocomposite could be a promising candidate for pH-responsive drug delivery system in the cancer therapy.
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