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Tytuł:
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Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting.
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Autorzy:
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Nishimoto Y; Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan.
Nagashima S; Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan.
Nakajima K; Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan.
Ohira T; Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan.
Sato T; Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan.
Izawa T; Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58, Rinku Orai Kita, Izumisano, Osaka 598-8531, Japan.
Yamate J; Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58, Rinku Orai Kita, Izumisano, Osaka 598-8531, Japan.
Higashikawa K; Central Institutes of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido 060-0815, Japan.
Kuge Y; Central Institutes of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido 060-0815, Japan.
Ogawa M; Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan.
Kojima C; Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan. Electronic address: .
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Źródło:
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International journal of pharmaceutics [Int J Pharm] 2020 Feb 25; Vol. 576, pp. 119021. Date of Electronic Publication: 2020 Jan 07.
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Typ publikacji:
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Comparative Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
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MeSH Terms:
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Drug Carriers*
Nanoparticles*
Optical Imaging*
Dendrimers/*pharmacokinetics
Fluorescent Dyes/*pharmacokinetics
Lymph Nodes/*metabolism
Animals ; Dendrimers/administration & dosage ; Dendrimers/chemical synthesis ; Drug Compounding ; Female ; Fluorescent Dyes/administration & dosage ; Fluorescent Dyes/chemistry ; Injections, Intradermal ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/immunology ; Mice, Inbred BALB C ; Phosphorylation ; Tissue Distribution
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Contributed Indexing:
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Keywords: Anionic; Dendrimer; Immune cells; Intradermal injection; Lymph node; Targeting
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Substance Nomenclature:
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0 (Dendrimers)
0 (Drug Carriers)
0 (Fluorescent Dyes)
0 (PAMAM Starburst)
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Entry Date(s):
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Date Created: 20200110 Date Completed: 20201116 Latest Revision: 20201116
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Update Code:
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20240105
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DOI:
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10.1016/j.ijpharm.2020.119021
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PMID:
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31917298
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The development of drug delivery vehicles to cancer and/or immune cells in lymph nodes is important for cancer diagnosis, therapy, and immunotherapy. We previously reported that anionic carboxyl-terminal dendrimers were accumulated in lymph nodes. In this study, three anionic dendrimers with carboxyl-, sulfonyl-, and phosphate-terminal groups were prepared to examine the lymph node targeting and the association with immune cells in the lymph nodes. These anionic dendrimers were accumulated in the lymph node by intradermal injection. Although the carboxyl- and sulfonyl-terminal dendrimers were diffused from the injection site, the phosphate-terminal dendrimers were mostly retained. The phosphate-terminal dendrimer was recognized by the macrophages, dendritic cells, and B cells in the lymph node, whereas the carboxyl- and sulfonyl-terminal dendrimers were not. Our results show that these anionic dendrimers were accumulated in the lymph node where the association with immune cells could be controlled by the terminal structure of the dendrimer. The phosphate-terminal dendrimer can be used as a nanoplatform for the delivery of some bioactive molecules to some immune cells, including B cells, in the lymph node.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest directly relevant to the content of this article.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
