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Tytuł:
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Human arsenic exposure and lung function impairment in coal-burning areas in Guizhou, China.
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Autorzy:
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Wang W; The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, 550025, Guizhou, PR China.
Wang Q; The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, 550025, Guizhou, PR China.
Zou Z; The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, 550025, Guizhou, PR China.
Zheng F; The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, 550025, Guizhou, PR China.
Zhang A; The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang, 550025, Guizhou, PR China. Electronic address: .
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Źródło:
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Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Mar 01; Vol. 190, pp. 110174. Date of Electronic Publication: 2020 Jan 08.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Netherlands : Elsevier
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MeSH Terms:
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Coal*
Arsenic/*analysis
Arsenic Poisoning/*physiopathology
Environmental Pollutants/*analysis
Lung/*physiopathology
Adult ; Arsenic Poisoning/blood ; Arsenic Poisoning/epidemiology ; Arsenic Poisoning/metabolism ; Biological Monitoring ; China/epidemiology ; Female ; Hair/chemistry ; Humans ; Male ; Matrix Metalloproteinase 9/blood ; Middle Aged ; Pulmonary Surfactant-Associated Protein A/blood ; Respiratory Function Tests ; Tissue Inhibitor of Metalloproteinase-1/blood ; Uteroglobin/blood
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Contributed Indexing:
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Keywords: Arsenic exposure; Coal-burning arsenicosis; Hair arsenic; Lung function; Serum inflammatory marker
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Substance Nomenclature:
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0 (Coal)
0 (Environmental Pollutants)
0 (Pulmonary Surfactant-Associated Protein A)
0 (SCGB1A1 protein, human)
0 (TIMP1 protein, human)
0 (Tissue Inhibitor of Metalloproteinase-1)
9060-09-7 (Uteroglobin)
EC 3.4.24.35 (MMP9 protein, human)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
N712M78A8G (Arsenic)
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Entry Date(s):
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Date Created: 20200114 Date Completed: 20200406 Latest Revision: 20200408
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Update Code:
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20240105
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DOI:
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10.1016/j.ecoenv.2020.110174
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PMID:
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31927192
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To evaluate the effect of coal-burning arsenic (As) exposure on lung function and the potential underlying mechanisms, a total of 217 As-exposed subjects and 75 reference subjects were recruited into this study. Hair arsenic (H-As), pulmonary function tests, and serum inflammatory markers CC16, SP-A, MMP-9, and TIMP-1 were evaluated. Residents from As-exposed areas showed higher H-As concentrations (median 0.25 μg/g) than subjects from the reference area (median 0.14 μg/g). Large reductions in lung function parameters were noted in the As-exposed group. A significant negative correlation was observed between H-As concentrations and lung function. Specifically, monotonic negative dose-response relationships were observed between H-As and FEV1(%), FEV1/FVC (%) and FEF75 (%) (all P < 0.05), while the associations between H-As and FVC (%), FEF25 (%), and FEF50 (%) were nonlinear (P for nonlinearity = 0.03, 0.001, 0.01, respectively). In addition, there was a direct positive relationship between H-As and the inflammatory response. Alterations in inflammatory biomarkers (CC16, SP-A, MMP-9, and MMP-9/TIMP-1) were significantly associated with As-induced lung function impairment. Thus, this population-based study revealed that As exposure has significant toxic effects on lung function and increased inflammation may occur during this toxic process. We provide scientific evidence for an As-induced alteration in inflammatory biomarkers and pulmonary damage in an As-exposed population. The results of this study can inform risk assessment and risk control processes in relation to human As exposure in coal-burning arsenicosis areas.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
