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Tytuł pozycji:

Does [18F] fluorodeoxyglucose-positron emission tomography/computed tomography have a role in cervical nodal staging for esophageal squamous cell carcinoma?

Tytuł :
Does [18F] fluorodeoxyglucose-positron emission tomography/computed tomography have a role in cervical nodal staging for esophageal squamous cell carcinoma?
Autorzy :
Li B; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Li N; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.
Liu S; Department of Thoracic Surgery, Fujian Medical University Cancer Hospital, Fuzhou, China.
Li Y; Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Beijing, China.
Qian B; Department of Thoracic Surgery, Jiangdu People's Hospital of Yangzhou, Jiangdu, China.
Zhang Y; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
He H; Department of Thoracic Surgery, Fujian Medical University Cancer Hospital, Fuzhou, China.
Chen X; Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Beijing, China.
Sun Y; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Xiang J; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Hu H; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: .
Chen H; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: .
Pokaż więcej
Źródło :
The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2020 Aug; Vol. 160 (2), pp. 544-550. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji :
Journal Article; Multicenter Study; Video-Audio Media
Język :
English
Imprint Name(s) :
Publication: St. Louis, MO : Mosby
Original Publication: St. Louis.
MeSH Terms :
Neoplasm Staging*
Positron Emission Tomography Computed Tomography*
Esophageal Neoplasms/*diagnostic imaging
Esophageal Squamous Cell Carcinoma/*diagnostic imaging
Fluorodeoxyglucose F18/*administration & dosage
Lymph Nodes/*diagnostic imaging
Radiopharmaceuticals/*administration & dosage
Aged ; China ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma/secondary ; Esophageal Squamous Cell Carcinoma/surgery ; Esophagectomy ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies
Contributed Indexing :
Keywords: FDG-PET/CT; cervical nodal staging; esophageal cancer; lymph node metastases
Substance Nomenclature :
0 (Radiopharmaceuticals)
0Z5B2CJX4D (Fluorodeoxyglucose F18)
Entry Date(s) :
Date Created: 20200115 Date Completed: 20200803 Latest Revision: 20200803
Update Code :
20201023
DOI :
10.1016/j.jtcvs.2019.11.046
PMID :
31932053
Czasopismo naukowe
Objective: Accurate nodal staging is crucial for esophageal cancer. A prospective study was performed to assess the value of [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) for diagnosing cervical lymph node metastasis (LNM) of esophageal squamous cell carcinoma.
Methods: From June 2018 to November 2018, 110 patients with resectable esophageal cancer were prospectively enrolled. Esophagectomy with 3-field lymphadenectomy was performed after FDG-PET/CT scanning. The primary end point was cervical LNM determined via postoperative histologic examination. The sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and accuracy (AC) of FDG-PET/CT for the assessment of LNM were determined using histologic results as reference standards.
Results: Positive lymph nodes as determined via FDG-PET/CT were detected in 61 patients (55.5%), of whom 13 (11.8%) had positive cervical lymph nodes. After surgery, 59 patients (53.6%) exhibited pathologic LNM, of whom 20 (18.2%) had cervical LNM. SE, SP, PPV, NPV, and AC were 65.6%, 61.2%, 67.8%, 58.8%, and 63.6%, respectively, with regards to diagnosing overall LNM, and were 45.0%, 95.6%, 69.2%, 88.7%, and 86.4%, respectively, for diagnosing cervical LNM. Of the 110 patients, 90 underwent both FDG-PET/CT scanning and ultrasonography in the neck, and there were no significant differences in SE, SP, PPV, NPV, or AC with respect to cervical LNM diagnosis between FDG-PET/CT and ultrasonography.
Conclusions: For cervical LNM of esophageal squamous cell carcinoma, FDG-PET/CT scanning exhibited high specificity but low sensitivity, suggesting that it is of limited value for this purpose.
(Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
Comment in: J Thorac Cardiovasc Surg. 2020 Aug;160(2):553-554. (PMID: 31926715)
Comment in: J Thorac Cardiovasc Surg. 2020 Aug;160(2):551-552. (PMID: 31955937)

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