Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases.

Szczegóły
Abstrakt

Tytuł:: Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases.
Autorzy:: Méchin MC; UDEAR, Institut National de la Santé Et de la Recherche Médicale, Université Paul Sabatier, Université de Toulouse Midi-Pyrénées, U1056, Toulouse 31059, France.
Takahara H; University of Ibaraki, School of Agriculture, Ibaraki 300-0393, Japan.
Simon M; UDEAR, Institut National de la Santé Et de la Recherche Médicale, Université Paul Sabatier, Université de Toulouse Midi-Pyrénées, U1056, Toulouse 31059, France.
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Jan 15; Vol. 21 (2). Date of Electronic Publication: 2020 Jan 15.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:: Gene Expression Regulation*
Protein Processing, Post-Translational*
Protein-Arginine Deiminases/*genetics
Skin Diseases/*genetics
Skin Physiological Phenomena/*genetics
Citrullination ; Homeostasis/genetics ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Keratinocytes/metabolism ; Protein-Arginine Deiminases/metabolism ; Skin/metabolism ; Skin/pathology ; Skin Diseases/metabolism
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Contributed Indexing:: Keywords: alopecia; citrullination; differentiation; epidermis; hair; keratinocyte; peptidylarginine deiminase; posttranslational modification
Substance Nomenclature:: 0 (Isoenzymes)
EC 3.5.3.15 (Protein-Arginine Deiminases)
Entry Date(s):: Date Created: 20200119 Date Completed: 20201005 Latest Revision: 20201005
Update Code:: 20240104
PubMed Central ID:: PMC7014782
DOI:: 10.3390/ijms21020566
PMID:: 31952341
: Czasopismo naukowe

Pełny tekst

Deimination, also known as citrullination, corresponds to the conversion of the amino acid arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post-translational modification is catalyzed by a family of calcium-dependent enzymes called peptidylarginine deiminases (PADs). Deimination is implicated in a growing number of physiological processes (innate and adaptive immunity, gene regulation, embryonic development, etc.) and concerns several human diseases (rheumatoid arthritis, neurodegenerative diseases, female infertility, cancer, etc.). Here, we update the involvement of PADs in both the homeostasis of skin and skin diseases. We particularly focus on keratinocyte differentiation and the epidermal barrier function, and on hair follicles. Indeed, alteration of PAD activity in the hair shaft is responsible for two hair disorders, the uncombable hair syndrome and a particular form of inflammatory scarring alopecia, mainly affecting women of African ancestry.
Competing Interests: H.T. declares no conflict of interest. M.-C.M. and M.S. are co-inventors of a patent (n°WO2012140095A1) concerning acefylline use in cosmetics.

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