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Tytuł:
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MiR-202-3p Inhibits Foam Cell Formation and is Associated with Coronary Heart Disease Risk in a Chinese Population.
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Autorzy:
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Li L; Research Center of Translational Medicine, The Second Affiliated Hospital of Shantou University Medical College.
Wu F; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University.
Xie Y; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University.
Xu W; Research Center of Translational Medicine, The Second Affiliated Hospital of Shantou University Medical College.
Xiong G; Medical Big Data Research Center, The Second Affiliated Hospital of Nanchang University.
Xu Y; Medical Big Data Research Center, The Second Affiliated Hospital of Nanchang University.
Huang S; Department of Molecular Epidemiology, Shenzhen Center for Disease Control and Prevention.
Wu Y; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University.
Jiang X; Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University.
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Źródło:
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International heart journal [Int Heart J] 2020 Jan 31; Vol. 61 (1), pp. 153-159. Date of Electronic Publication: 2020 Jan 17.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [Tokyo, Japan] : International Heart Journal Association, [2005]-
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MeSH Terms:
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Asian People/*genetics
Coronary Disease/*genetics
Foam Cells/*cytology
MicroRNAs/*genetics
Aged ; Case-Control Studies ; Cells, Cultured ; Female ; Foam Cells/metabolism ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Lipoproteins, LDL/metabolism ; Macrophages/cytology ; Macrophages/metabolism ; Male ; Middle Aged ; THP-1 Cells ; Up-Regulation
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Contributed Indexing:
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Keywords: ABCG4; NCEH1; Platelet parameters; SCARB2
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Substance Nomenclature:
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0 (Lipoproteins, LDL)
0 (MIRN202 microRNA, human)
0 (MicroRNAs)
0 (oxidized low density lipoprotein)
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Entry Date(s):
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Date Created: 20200121 Date Completed: 20200219 Latest Revision: 20221207
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Update Code:
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20240104
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DOI:
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10.1536/ihj.19-033
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PMID:
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31956131
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A previous study and a gene-annotation enrichment analysis for potential targets of the microRNA miR-202-3p both suggest that this microRNA might be implicated in cardiovascular and metabolic diseases. In the present study, the role of miR-202-3p in the pathogenesis of coronary heart disease (CHD) was explored. We conduct a case-control study to detect the expression levels of miR-202-3p in peripheral blood cells and found that miR-202-3p expression was significantly higher in CHD cases than in controls (P < 0.001). miR-202-3p levels were negatively correlated with platelet distribution width (r = -0.348, P = 0.002) and mean platelet volume (r = -0.29, P = 0.01). Further functional analyses suggested that stimulation with oxidized low-density lipoprotein (ox-LDL) induced miR-202-3p expression, and that this microRNA suppressed the formation of ox-LDL-induced macrophage foam cells derived from THP-1 cells in a feedback manner. In addition, miR-202-3p overexpression modulated the expression of several key genes involved in foam cell formation, including that of ABCG4, NCEH1I, and SCARB2. In summary, miR-202-3p was associated with CHD, exerting a protective role against CHD by feedback suppression of ox-LDL-induced macrophage foam cell formation.