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Tytuł:
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Evaluating the role of sentinel lymph node biopsy in patients with DCIS treated with breast conserving surgery.
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Autorzy:
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James TA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States; Quality Integration Committee, Commission on Cancer, American College of Surgeons, United States. Electronic address: .
Palis B; Quality Integration Committee, Commission on Cancer, American College of Surgeons, United States.
McCabe R; National Cancer Database, Commission on Cancer, American College of Surgeons, United States.
Pardo JA; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Alapati A; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Ukandu O; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Serres SK; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Zhang J; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Mele A; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, United States.
Facktor M; Quality Integration Committee, Commission on Cancer, American College of Surgeons, United States; Department of Surgery, Geisinger Medical System, United States.
Shulman LN; National Cancer Database, Commission on Cancer, American College of Surgeons, United States; Abramson Cancer Center, University of Pennsylvania, United States.
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Źródło:
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American journal of surgery [Am J Surg] 2020 Sep; Vol. 220 (3), pp. 654-659. Date of Electronic Publication: 2020 Jan 13.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Belle Mead, NJ : Excerpta Medica
Original Publication: New York.
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MeSH Terms:
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Mastectomy, Segmental*
Sentinel Lymph Node Biopsy*
Breast Neoplasms/*pathology
Breast Neoplasms/*surgery
Carcinoma, Intraductal, Noninfiltrating/*pathology
Carcinoma, Intraductal, Noninfiltrating/*surgery
Procedures and Techniques Utilization/*statistics & numerical data
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Middle Aged ; Treatment Outcome ; Young Adult
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Entry Date(s):
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Date Created: 20200123 Date Completed: 20201125 Latest Revision: 20201125
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Update Code:
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20240104
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DOI:
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10.1016/j.amjsurg.2020.01.014
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PMID:
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31964523
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Introduction: The role of sentinel lymph node biopsy (SLNB) for patients with ductal carcinoma in-situ (DCIS) is limited given the rarity of nodal metastasis in non-invasive disease. Although SLNB is typically a safe procedure, there are potential complications and associated costs. The purpose of this study is to assess national surgical practice patterns and clinical outcomes with respect to the use of SLNB for DCIS in patients undergoing breast conserving surgery (BCS).
Methods: Case-level data from the National Cancer Data Base (NCDB) was assessed to identify adult patients ≥ 18 with DCIS, who underwent BCS and SLNB. Patient demographics and hospital characteristics were grouped for analytic purposes. A multivariate analysis was performed for patient and hospital characteristics.
Results: We identified 15,422 patients with DCIS undergoing BCS in 2015, of which 2,698 (18%) underwent SLNB. A multivariate analysis demonstrated a significant association between greater frequency of SLNB in patients age range of 60-69, receipt of care at a community facility, and higher nuclear grade DCIS. Positive sentinel nodes metastasis was identified in 0.9% patients undergoing BCS and SLNB for DCIS.
Conclusion: The role of SLNB in patients with DCIS undergoing BCS is limited and does not routinely provide meaningful information or benefit to clinical management. Despite this, nearly one in five patients undergoing BCS for DCIS had lymph node sampling performed. Given the potential increased morbidity and financial implications, this finding represents an opportunity for further education and improvement in patient selection for SLNB.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
