Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.

Tytuł:: Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.
Autorzy:: Bertoldi AD; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Rifas-Shiman SL; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Boing AC; Department of Public Health, Postgraduate Program in Public Health, Federal University of Santa Catarina, Florianópolis, Brazil.
da Silva Dal Pizzol T; Medicines Production and Control Department, Pharmacy College and Post Graduate Program in Epidemiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Miranda VIA; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Silveira MPT; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; Department of Physiology and Pharmacology, Federal University of Pelotas, Pelotas, Brazil.
Freitas Silveira M; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Domingues MR; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; Post-Graduate Program in Physical Education, Federal University of Pelotas, Pelotas, Brazil.
Santos IS; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; Post-graduate Program in Pediatrics and Child Health, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Bassani DG; Centre for Global Child Health, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Tovo-Rodrigues L; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Oken E; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Źródło:: Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2020 May; Vol. 34 (3), pp. 267-277. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: Oxford ; Boston : Blackwell Scientific Publications, [c1987-
MeSH Terms:: Acetaminophen*/adverse effects
Acetaminophen*/therapeutic use
Neurodevelopmental Disorders*/chemically induced
Neurodevelopmental Disorders*/diagnosis
Neurodevelopmental Disorders*/epidemiology
Pregnancy Complications*/drug therapy
Pregnancy Complications*/epidemiology
Pregnancy Trimesters*
Prenatal Exposure Delayed Effects*/chemically induced
Prenatal Exposure Delayed Effects*/diagnosis
Prenatal Exposure Delayed Effects*/epidemiology
Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/therapeutic use ; Brazil/epidemiology ; Child Behavior/drug effects ; Child Development/drug effects ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Infant ; Male ; Nonprescription Drugs/adverse effects ; Nonprescription Drugs/therapeutic use ; Pregnancy ; United States/epidemiology
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Grant Information:: 095582 United Kingdom WT_ Wellcome Trust; R01 HD034568 United States HD NICHD NIH HHS; UH3 OD023286 United States OD NIH HHS; R01 HD034568, UH3 OD023286 United States NH NIH HHS
Contributed Indexing:: Keywords: acetaminophen; cohort studies; infant; neurodevelopmental disorders; pregnancy
Substance Nomenclature:: 0 (Analgesics, Non-Narcotic)
0 (Nonprescription Drugs)
362O9ITL9D (Acetaminophen)
Entry Date(s):: Date Created: 20200123 Date Completed: 20210503 Latest Revision: 20230816
Update Code:: 20240104
PubMed Central ID:: PMC7192774
DOI:: 10.1111/ppe.12632
PMID:: 31965601
: Czasopismo naukowe

Pełny tekst

Background: Over-the-counter analgesic use during pregnancy, particularly acetaminophen, may be associated with negative developmental outcomes in children.
Objective: Estimate associations of prenatal and early-life exposure to acetaminophen in early childhood with cognitive, motor, and language skills in two birth cohorts.
Methods: The American Project Viva cohort (1217 mother-child pairs enrolled 1999-2002) assessed cognition at approximately 3 years using the Peabody Picture Vocabulary Test and the Wide Range Achievement of Visual Motor Abilities (WRAVMA). The Brazilian 2015 Pelotas Birth Cohort (3818 mother-child pairs) assessed cognition at 2 years using the INTERGROWTH-21st Neurodevelopment Assessment. We used linear regression to estimate associations of acetaminophen use during pregnancy (Project Viva and Pelotas) and infancy (Project Viva) with children's cognitive scores adjusted for maternal age, pre-pregnancy body mass index, education, parity, race/ethnicity, smoking and alcohol use during pregnancy, depression during pregnancy, antibiotic and ibuprofen use during pregnancy, household income, and child's sex.
Results: In Project Viva, exposure to acetaminophen in both the 1st and 2nd trimester of pregnancy was associated with lower WRAVMA drawing scores (β -1.51, 95% CI -2.92, -0.10). However, in Pelotas, exposure to acetaminophen in both the 1st and 2nd trimester of pregnancy was not associated with INTER-NDA motor scores (β 0.02; 95% CI -0.05, 0.09) and was associated with higher INTER-NDA total scores (β 0.08, 95% CI 0.01, 0.16). Other comparisons did not show evidence for any associations.
Conclusions: Inconsistencies and lack of specificity of the findings did not clarify the research question considering that we still have a large variability and uncertainty to define the risk or safety in the use of acetaminophen related to cognition in early childhood. More studies using better exposure assessment and better confounding variables are needed to clarify these associations.
(© 2020 John Wiley & Sons Ltd.)

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