Hebbian-Type Primary Motor Cortex Stimulation: A Potential Treatment of Impaired Hand Function in Chronic Stroke Patients.

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Abstrakt

Tytuł:: Hebbian-Type Primary Motor Cortex Stimulation: A Potential Treatment of Impaired Hand Function in Chronic Stroke Patients.
Autorzy:: Revill KP; Emory University, Atlanta, GA, USA.
Haut MW; West Virginia University School of Medicine, Morgantown, WV, USA.
Belagaje SR; Emory University, Atlanta, GA, USA.
Nahab F; Emory University, Atlanta, GA, USA.
Drake D; University of Michigan, Ann Arbor, MI, USA.
Buetefisch CM; Emory University, Atlanta, GA, USA.
Źródło:: Neurorehabilitation and neural repair [Neurorehabil Neural Repair] 2020 Feb; Vol. 34 (2), pp. 159-171. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji:: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2002- : Thousand Oaks, CA : Sage Publications
Original Publication: New York, NY : Demos Medical Pub., c1999-
MeSH Terms:: Outcome Assessment, Health Care*
Transcranial Magnetic Stimulation*
Hand/*physiopathology
Ischemic Stroke/*physiopathology
Ischemic Stroke/*therapy
Motor Cortex/*physiopathology
Neuronal Plasticity/*physiology
Stroke Rehabilitation/*methods
Adult ; Aged ; Chronic Disease ; Double-Blind Method ; Female ; Humans ; Ischemic Stroke/diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Cortex/diagnostic imaging
References:: Nature. 1996 Aug 29;382(6594):805-7. (PMID: 8752272)
J Neurosci. 1996 Jan 15;16(2):785-807. (PMID: 8551360)
Phys Ther. 1987 Feb;67(2):206-7. (PMID: 3809245)
Neurorehabil Neural Repair. 2015 Feb;29(2):193-202. (PMID: 25009222)
Nat Neurosci. 1998 Jul;1(3):230-4. (PMID: 10195148)
PLoS One. 2015 Oct 06;10(10):e0139746. (PMID: 26440276)
J Neurosci. 2004 Jan 21;24(3):628-33. (PMID: 14736848)
J Neurophysiol. 2014 Aug 15;112(4):999-1009. (PMID: 24848477)
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3661-5. (PMID: 10716702)
Neural Plast. 2018 Mar 12;2018:9867196. (PMID: 29721009)
J Rehabil Res Dev. 2006 May-Jun;43(3):401-8. (PMID: 17041825)
Cereb Cortex. 2008 Mar;18(3):638-47. (PMID: 17602141)
J Neurophysiol. 2003 Aug;90(2):1160-70. (PMID: 12660350)
J Neurophysiol. 1996 May;75(5):1826-42. (PMID: 8734583)
Clin Neurophysiol. 2004 Feb;115(2):255-66. (PMID: 14744565)
Am J Occup Ther. 1992 Jul;46(7):647-9. (PMID: 1621801)
Stroke. 2007 Jul;38(7):2108-14. (PMID: 17540966)
Electroencephalogr Clin Neurophysiol. 1994 Aug;91(2):79-92. (PMID: 7519144)
Neural Plast. 2016;2016:2643491. (PMID: 26839711)
J Neurosci. 2001 Apr 15;21(8):2784-92. (PMID: 11306630)
Arch Phys Med Rehabil. 1969 Jun;50(6):311-9. (PMID: 5788487)
Neuroimage. 2008 Feb 1;39(3):1215-26. (PMID: 18023365)
Neuroimage. 2012 Jul 16;61(4):1402-18. (PMID: 22430496)
Brain Struct Funct. 2015 Mar;220(2):1093-107. (PMID: 24415059)
J Neurophysiol. 1991 Jun;65(6):1435-41. (PMID: 1875252)
Neurol Res. 2003 Dec;25(8):801-10. (PMID: 14669522)
Exp Brain Res. 2018 Jul;236(7):2009-2021. (PMID: 29730752)
Neurology. 2006 Oct 10;67(7):1189-94. (PMID: 17030751)
Br J Soc Clin Psychol. 1967 Dec;6(4):278-96. (PMID: 6080235)
Front Neurol. 2015 Oct 16;6:214. (PMID: 26528236)
Neurorehabil Neural Repair. 2017 Aug;31(8):694-698. (PMID: 28803534)
Clin Neurophysiol. 2009 Dec;120(12):2008-2039. (PMID: 19833552)
Neuroimage. 2012 Feb 1;59(3):2771-82. (PMID: 22023742)
Science. 1996 Jun 21;272(5269):1791-4. (PMID: 8650578)
J Clin Exp Neuropsychol. 1998 Jun;20(3):310-9. (PMID: 9845158)
Comput Biomed Res. 1996 Jun;29(3):162-73. (PMID: 8812068)
J Physiol. 2012 Apr 1;590(7):1669-82. (PMID: 22250210)
J Neurophysiol. 2003 May;89(5):2339-45. (PMID: 12612033)
Neurorehabil Neural Repair. 2011 Sep;25(7):645-55. (PMID: 21606211)
Phys Ther. 1992 May;72(5):373-7. (PMID: 1631206)
Brain Res. 1987 Oct 13;423(1-2):378-84. (PMID: 2823992)
Brain. 2012 Jul;135(Pt 7):2277-89. (PMID: 22581799)
J Neurol Sci. 1995 May;130(1):59-68. (PMID: 7650532)
J Neurophysiol. 2018 Oct 1;120(4):1680-1694. (PMID: 29924707)
Neurol Res. 2003 Dec;25(8):789-93. (PMID: 14669520)
Neuropsychologia. 1971 Mar;9(1):97-113. (PMID: 5146491)
PLoS One. 2013 May 28;8(5):e64154. (PMID: 23724030)
Prog Brain Res. 2011;192:273-95. (PMID: 21763529)
Neurorehabil Neural Repair. 2015 Jul;29(6):590-8. (PMID: 25323461)
Stroke. 2005 Mar;36(3):630-4. (PMID: 15677573)
Brain Res. 1985 Sep;357(1):1-26. (PMID: 4041923)
Clin Rehabil. 2000 Feb;14(1):14-9. (PMID: 10688340)
J Neurophysiol. 2004 May;91(5):2110-6. (PMID: 14711974)
Clin Neurophysiol. 2015 Mar;126(3):581-93. (PMID: 25113275)
J Neurophysiol. 2000 Aug;84(2):986-1005. (PMID: 10938322)
Grant Information:: R01 NS090677 United States NS NINDS NIH HHS; R21 HD067906 United States HD NICHD NIH HHS
Contributed Indexing:: Keywords: chronic stroke; functional magnetic resonance imaging (fMRI); hand function; neurorehabilitation; transcranial magnetic stimulation (TMS)
Molecular Sequence:: ClinicalTrials.gov NCT01569607
Entry Date(s):: Date Created: 20200125 Date Completed: 20210125 Latest Revision: 20210125
Update Code:: 20240104
PubMed Central ID:: PMC7012764
DOI:: 10.1177/1545968319899911
PMID:: 31976804
: Czasopismo naukowe

Background. Stroke often involves primary motor cortex (M1) and its corticospinal (CST) projections. As hand function is critically dependent on these structures, its recovery is often incomplete. Objective. To determine whether impaired hand function in patients with chronic ischemic stroke involving M1 or CST benefits from the enhancing effect of Hebbian-type stimulation (pairing M1 afferent stimulation and M1 activity in a specific temporal relationship) on M1 plasticity and hand function. Methods. In a double-blind, randomized, sham-controlled design, 20 patients with chronic ischemic stroke affecting M1 or CST were randomly assigned to 5 days of hand motor training that was combined with either Hebbian-type (training Hebb ) or sham stimulation (training sham ) of the lesioned M1. Measures of hand function and task-based M1 functional magnetic resonance imaging (fMRI) activity were collected prior to, immediately following, and 4 weeks after the intervention. Results. Both interventions were effective in improving affected hand function at the completion of training, but only participants in the training Hebb group maintained functional gains. Changes in hand function and fMRI activity were positively correlated in both ipsilesional and contralesional M1. Compared with training sham , participants in the training Hebb group showed a stronger relationship between improved hand function and changes in M1 functional activity. Conclusions. Only when motor training was combined with Hebbian-type stimulation were functional gains maintained over time and correlated with measures of M1 functional plasticity. As hand dexterity is critically dependent on M1 function, these results suggest that functional reorganization in M1 is facilitated by Hebbian-type stimulation. ClinicalTrials.gov Identifier: NCT01569607.

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