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Tytuł:
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Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin.
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Autorzy:
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Kokelj S; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kim JL; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Andersson M; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Runström Eden G; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bake B; Unit of Respiratory Medicine and Allergy, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Olin AC; Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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Źródło:
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PloS one [PLoS One] 2020 Jan 24; Vol. 15 (1), pp. e0227980. Date of Electronic Publication: 2020 Jan 24 (Print Publication: 2020).
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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Albumins/*isolation & purification
Pulmonary Disease, Chronic Obstructive/*diagnosis
Pulmonary Surfactant-Associated Protein A/*isolation & purification
Respiratory System/*chemistry
Adult ; Aged ; Air/analysis ; Albumins/metabolism ; Biomarkers/chemistry ; Breath Tests ; Exhalation/physiology ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Surfactant-Associated Protein A/metabolism ; Respiratory System/metabolism ; Spirometry/methods
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References:
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Substance Nomenclature:
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0 (Albumins)
0 (Biomarkers)
0 (Pulmonary Surfactant-Associated Protein A)
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SCR Disease Name:
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Pulmonary Disease, Chronic Obstructive, Severe Early-Onset
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Entry Date(s):
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Date Created: 20200125 Date Completed: 20200415 Latest Revision: 20200415
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Update Code:
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20240104
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PubMed Central ID:
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PMC6980535
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DOI:
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10.1371/journal.pone.0227980
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PMID:
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31978133
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Introduction: Particles in exhaled air (PEx) provide samples of respiratory tract lining fluid from small airways containing, for example, Surfactant protein A (SP-A) and albumin, potential biomarkers of small airway disease. We hypothesized that there are differences between morning, noon, and afternoon measurements and that the variability of repeated measurements is larger between days than within days.
Methods: PEx was obtained in sixteen healthy non-smoking adults on 11 occasions, within one day and between days. SP-A and albumin were quantified by ELISA. The coefficient of repeatability (CR), intraclass correlation coefficient (ICC), and coefficient of variation (CV) were used to assess the variation of repeated measurements.
Results: SP-A and albumin increased significantly from morning towards the noon and afternoon by 13% and 25% on average, respectively, whereas PEx number concentration and particle mean mass did not differ significantly between the morning, noon and afternoon. Between-day CRs were not larger than within-day CRs.
Conclusions: Time of the day influences the contents of SP-A and albumin in exhaled particles. The variation of repeated measurements was rather high but was not influenced by the time intervals between measurements.
Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: Björn Bake, Marianne Andersson and Gunilla Runström Eden are shareholders of PEXA® AB (www.PEXA.se) and Anna-Carin Olin is a board member (patent WO2009045163). This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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