Can gallic acid potentiate the antihyperglycemic effect of acarbose and metformin? Evidence from streptozotocin-induced diabetic rat model.

Tytuł:: Can gallic acid potentiate the antihyperglycemic effect of acarbose and metformin? Evidence from streptozotocin-induced diabetic rat model.
Autorzy:: Oboh G; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Ogunbadejo MD; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Ogunsuyi OB; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.; Biomedical Technology Department, Federal University of Technology, Akure, Nigeria.
Oyeleye SI; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.; Biomedical Technology Department, Federal University of Technology, Akure, Nigeria.
Źródło:: Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Jun; Vol. 128 (3), pp. 619-627. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: London : Informa Healthcare
Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995-
MeSH Terms:: Diabetes Mellitus, Experimental*/drug therapy
Metformin*/pharmacology
Metformin*/therapeutic use
Acarbose/pharmacology ; Acarbose/therapeutic use ; Animals ; Antioxidants/metabolism ; Blood Glucose ; Gallic Acid/pharmacology ; Gallic Acid/therapeutic use ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Insulin ; Rats ; Reactive Oxygen Species ; Streptozocin ; Thiobarbituric Acid Reactive Substances ; alpha-Amylases/metabolism ; alpha-Glucosidases/metabolism
Contributed Indexing:: Keywords: Antihyperglycemic; acarbose; food-drug interaction; gallic acid; metformin
Substance Nomenclature:: 0 (Antioxidants)
0 (Blood Glucose)
0 (Hypoglycemic Agents)
0 (Insulin)
0 (Reactive Oxygen Species)
0 (Thiobarbituric Acid Reactive Substances)
5W494URQ81 (Streptozocin)
632XD903SP (Gallic Acid)
9100L32L2N (Metformin)
EC 3.2.1.1 (alpha-Amylases)
EC 3.2.1.20 (alpha-Glucosidases)
T58MSI464G (Acarbose)
Entry Date(s):: Date Created: 20200126 Date Completed: 20220530 Latest Revision: 20220601
Update Code:: 20240104
DOI:: 10.1080/13813455.2020.1716014
PMID:: 31979987
: Czasopismo naukowe

Pełny tekst

This study investigated the influence of dietary phenolic acid- Gallic acid (GA) on the antihyperglycemic properties of acarbose (ACA) and metformin (MET). Streptozotocin-induced diabetic rats were treated ( p.o ) with ACA, MET, GA and their combinations for 14 days. The effects of the treatments on blood glucose and insulin levels, pancreas α-amylase and intestinal α-glucosidase activities, as well as thiobarbituric acid reactive species (TBARS), thiol and reactive oxygen species (ROS) levels, including antioxidant enzyme activities were investigated. A significant increase in blood glucose, insulin, ROS and TBARS levels, and impaired antioxidant status, as well as elevation in the activities of α-amylase and α-glucosidase observed in diabetic rats were ameliorated in the treatment groups. Hpwever, GA had varying effects on the antidiabetic properties of the drugs. Nevertheless, GA showed more potentiating effects on the antidiabetic effect of MET and these effects were better observed at the lower dose of GA.

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