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Tytuł:
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The benefits and mechanisms of exercise training for Parkinson's disease.
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Autorzy:
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Feng YS; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
Yang SD; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, Australia; Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
Tan ZX; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
Wang MM; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
Xing Y; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
Dong F; Department of Clinical Laboratory Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China.
Zhang F; Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China; Hebei Provincial Orthopedic Biomechanics Key Laboratory, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, PR China. Electronic address: .
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Źródło:
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Life sciences [Life Sci] 2020 Mar 15; Vol. 245, pp. 117345. Date of Electronic Publication: 2020 Jan 22.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
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MeSH Terms:
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Exercise Therapy*
Parkinson Disease/*therapy
Humans ; Parkinson Disease/physiopathology ; Treatment Outcome
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Contributed Indexing:
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Keywords: Dopamine; Exercise; Motor dysfunction; Parkinson's disease
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Entry Date(s):
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Date Created: 20200126 Date Completed: 20200323 Latest Revision: 20200323
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Update Code:
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20240104
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DOI:
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10.1016/j.lfs.2020.117345
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PMID:
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31981631
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Parkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substantia nigra. Currently, the main therapeutic method for PD is anti-Parkinson medications, including levodopa, madopar, sirelin, and so on. However, the effect of pharmacological treatment has its own limitations, the most significant of which is that the therapeutic effect of dopaminergic treatments gradually diminishes with time. Exercise training, as an adjunctive treatment and complementary therapy, can improve the plasticity of cortical striatum and increase the release of dopamine. Exercise training has been proven to effectively improve motor disorders (including balance, gait, risk of falls and physical function) and nonmotor disorders (such as sleep impairments, cognitive function and quality of life) in PD patients. In recent years, various types of exercise training have been used to treat PD. In this review, we summarise the exercise therapy mechanisms and the protective effects of different types of exercise training on PD patients.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
