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Tytuł pozycji:

Differences in biological activities between recombinant human paraoxonase 1 (rhPON1) subtype isozemys R/Q as antidotes against organophosphorus poisonings.

Tytuł :
Differences in biological activities between recombinant human paraoxonase 1 (rhPON1) subtype isozemys R/Q as antidotes against organophosphorus poisonings.
Autorzy :
Cui Y; Department of Emergency Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004, China. Electronic address: .
Zhao M; Department of Emergency Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, 110004, China. Electronic address: .
Han L; Specialist Clinics, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Shenyang, 110022, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Jun 01; Vol. 325, pp. 51-61. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article
Język :
English
Journal Info :
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol. Lett. Subsets: MEDLINE
Imprint Name(s) :
Publication: Amsterdam : Elsevier
Original Publication: Amsterdam, Elsevier/North Holland.
MeSH Terms :
Antidotes/*pharmacology
Aryldialkylphosphatase/*pharmacology
Organophosphate Poisoning/*drug therapy
Acetylcholinesterase/metabolism ; Animals ; Antidotes/chemistry ; Aryldialkylphosphatase/chemistry ; Brain/pathology ; Chlorpyrifos ; Cholinesterase Inhibitors/pharmacology ; Diazinon ; Humans ; Isoenzymes/chemistry ; Isoenzymes/pharmacology ; Lethal Dose 50 ; Male ; Organophosphate Poisoning/pathology ; Organothiophosphorus Compounds/poisoning ; Rats ; Rats, Wistar ; Recombinant Proteins/chemistry ; Recombinant Proteins/pharmacology
Contributed Indexing :
Keywords: Antidote; Organophosphorus poisoning; Paraoxonase; Paraoxonase 1; Subtype isozyme
Substance Nomenclature :
0 (Antidotes)
0 (Cholinesterase Inhibitors)
0 (Isoenzymes)
0 (Organothiophosphorus Compounds)
0 (Recombinant Proteins)
998NGA2Q61 (carbophenothion)
EC 3.1.1.7 (Acetylcholinesterase)
EC 3.1.8.1 (Aryldialkylphosphatase)
EC 3.1.8.1 (PON1 protein, human)
JCS58I644W (Chlorpyrifos)
YUS1M1Q929 (Diazinon)
Entry Date(s) :
Date Created: 20200126 Date Completed: 20200330 Latest Revision: 20200330
Update Code :
20200716
DOI :
10.1016/j.toxlet.2020.01.017
PMID :
31981688
Czasopismo naukowe
Paraoxonase 1 (PON1) is a type of aromatic esterase widely existing in mammals. It can hydrolyze various kinds of compounds effectively in vivo and in vitro. Previous studies have confirmed that PON1 can be used as antidote against organophosphorus poisonings (OPs). In this study, we obtained two subtype isozymes (i.e. rhPON1 R192 and rhPON1 Q192 ) by gene recombination and compared their detoxification effects against different OPs in rats. The rhPON1 R192 demonstrated better detoxification effect against chlorpyrifos poisoning than the rhPON1 Q192 , whose detoxification effect against diazinon poisoning was prior to the former. Both of them showed poor detoxification effect against trithion. Therefore, we concluded that, to different OPs, better detoxification effect may be achieved by selecting the PON1 subtype isozyme with higher specific hydrolytic activity.
(Copyright © 2020. Published by Elsevier B.V.)

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