Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps.

Tytuł:: Quantitative analysis of therapeutic response in psoriatic arthritis of digital joints with Dual-energy CT iodine maps.
Autorzy:: Kayama R; Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan. reina_.
Fukuda T; Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Ogiwara S; Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Momose M; Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
Tokashiki T; Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Umezawa Y; Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
Asahina A; Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
Fukuda K; Department of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Źródło:: Scientific reports [Sci Rep] 2020 Jan 27; Vol. 10 (1), pp. 1225. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Absorptiometry, Photon/*methods
Arthritis, Psoriatic/*diagnostic imaging
Radiography, Dual-Energy Scanned Projection/*methods
Adult ; Aged ; Aged, 80 and over ; Arthritis, Psoriatic/therapy ; Contrast Media ; Feasibility Studies ; Female ; Finger Joint/pathology ; Foot Joints/pathology ; Humans ; Image Processing, Computer-Assisted/methods ; Iodine/metabolism ; Iodine/pharmacology ; Male ; Middle Aged ; Radiographic Image Enhancement/methods ; Reproducibility of Results ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome
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Substance Nomenclature:: 0 (Contrast Media)
9679TC07X4 (Iodine)
Entry Date(s):: Date Created: 20200129 Date Completed: 20200715 Latest Revision: 20210126
Update Code:: 20240105
PubMed Central ID:: PMC6985244
DOI:: 10.1038/s41598-020-58235-9
PMID:: 31988331
: Czasopismo naukowe

Pełny tekst

The aim of this study was to investigate the feasibility of quantitative assessment of the therapeutic response in psoriatic arthritis (PsA) by measuring iodine uptake using a Dual-energy CT (DECT) iodine map. The study included 74 symptomatic and 74 matching non-symptomatic joints of 26 consecutive PsA patients who underwent two contrast enhanced DECTs of the hand or foot, pre and post medical interventions. Symptomatic and matched non-symptomatic control joints were scored with the PsA DECT Scoring System (PsADECTS), which was derived by modifying the PsA MRI Scoring System (PsAMRIS), a recently validated scoring system that assesses PsA changes on MRI. Quantified iodine uptake measured using the DECT iodine map was compared to the PsADECTS score. Efficacy of PsA treatment was confirmed by the improved clinical findings. Both PsADECTS and iodine uptake also showed significant improvement after treatment (Wilcoxon signed-rank test: z = 7.38, p < 0.005; z = 6.20, p < 0.005, respectively). The treatment effects of PsADECTS score and iodine uptake showed a good correlation with each other (Spearman's ρ = 0.58 p < 0.005). Inter-reader agreement for PsADECTS score and iodine uptake were either moderate or good. In conclusion, our study showed that the DECT iodine map is a valid tool for quantitative assessment of the therapeutic response of PsA.

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