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Tytuł:
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Transplant outcomes in kidney recipients with lupus nephritis, and systematic review.
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Autorzy:
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Kim JE; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kim YC; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Min SL; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Lee H; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Ha J; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Chin HJ; Department of Internal Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
Kim YS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Han SS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
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Źródło:
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Lupus [Lupus] 2020 Mar; Vol. 29 (3), pp. 248-255. Date of Electronic Publication: 2020 Jan 29.
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Typ publikacji:
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Journal Article; Multicenter Study; Systematic Review
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Język:
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English
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Imprint Name(s):
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Publication: London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991-
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MeSH Terms:
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Kidney Failure, Chronic/*surgery
Kidney Transplantation/*adverse effects
Kidney Transplantation/*mortality
Lupus Nephritis/*surgery
Adult ; Disease Progression ; Female ; Graft Rejection/epidemiology ; Graft Survival ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/mortality ; Lupus Nephritis/diagnosis ; Lupus Nephritis/mortality ; Male ; Middle Aged ; Patient Safety ; Postoperative Complications/epidemiology ; Republic of Korea/epidemiology ; Retrospective Studies ; Survival Rate ; Time Factors ; Treatment Outcome ; Young Adult
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Contributed Indexing:
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Keywords: Graft survival; kidney transplantation; lupus nephritis; mortality; systemic lupus erythematosus
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Entry Date(s):
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Date Created: 20200131 Date Completed: 20201110 Latest Revision: 20201110
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Update Code:
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20240105
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DOI:
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10.1177/0961203320902524
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PMID:
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31996111
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Background: Despite improved survival of patients with lupus nephritis (LN), some require kidney transplantation because of progression to end-stage renal disease (ESRD). However, the transplant outcomes of these patients and other recipients have not been thoroughly compared.
Methods: In total, 1848 Korean kidney recipients who underwent transplantation from 1998 to 2017 at two tertiary referral centers were evaluated retrospectively. Among them, 28 recipients with LN, and 50 control recipients matched by age, sex, and donor type, were compared with respect to graft and patient survival. We pooled our data with 17 previous cohort studies in which the graft survival of recipients with LN was described in detail.
Results: During the median follow-up period of 9.5 years (maximum 21 years), graft failure (GF) occurred in 10.7% and 16.0% of LN and control recipients, respectively. No differences were found in the rates of GF and death-censored graft failure or patient survival between the two groups. The risks of acute T cell-mediated and antibody-mediated rejection were also similar between the two groups. The pooled analysis showed similar 1- and 5-year graft survival rates between LN and control recipients.
Conclusions: Kidney transplantation is an acceptable option in patients with concurrent LN and ESRD.
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