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Tytuł:
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Dynamic Post-Transcriptional Events Governing CD8 T Cell Homeostasis and Effector Function.
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Autorzy:
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Salerno F; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. Electronic address: .
Turner M; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK.
Wolkers MC; Department of Hematopoiesis, Sanquin Research, Landsteiner Laboratory, Amsterdam University Medical Centre (UMC), Amsterdam, and Oncode Institute, The Netherlands. Electronic address: .
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Źródło:
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Trends in immunology [Trends Immunol] 2020 Mar; Vol. 41 (3), pp. 240-254. Date of Electronic Publication: 2020 Jan 29.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Oxford, UK : Elsevier Science Ltd., c2001-
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MeSH Terms:
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CD8-Positive T-Lymphocytes*/immunology
Cytokines*/genetics
Cytokines*/immunology
Gene Expression Regulation*/immunology
Homeostasis*/immunology
RNA Processing, Post-Transcriptional*/immunology
Signal Transduction*
Lymphocyte Activation ; RNA-Binding Proteins/immunology
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Substance Nomenclature:
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0 (Cytokines)
0 (RNA-Binding Proteins)
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Entry Date(s):
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Date Created: 20200203 Date Completed: 20210316 Latest Revision: 20210316
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Update Code:
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20240105
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DOI:
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10.1016/j.it.2020.01.001
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PMID:
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32007423
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Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude and timing of cytokine production in CD8 + T cells. We discuss the dynamic features of post-transcriptional control during CD8 + T cell homeostasis and activation, and focus on the crosstalk between cell signaling and RNA-binding proteins. Elucidating gene-specific regulatory circuits may help in the future to rectify dysfunctional T cell responses.
(Copyright © 2020. Published by Elsevier Ltd.)
