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Tytuł pozycji:

Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation.

Tytuł:
Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation.
Autorzy:
Yattah C; Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of the City University of New York, 85 St. Nicholas Terrace, New York, NY, 10031, USA.; Graduate Program in Biochemistry, The Graduate Center of The City University of New York, 365 5th Avenue, New York, NY, 10016, USA.
Hernandez M; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Huang D; Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of the City University of New York, 85 St. Nicholas Terrace, New York, NY, 10031, USA.; Graduate Program in Biochemistry, The Graduate Center of The City University of New York, 365 5th Avenue, New York, NY, 10016, USA.
Park H; Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of the City University of New York, 85 St. Nicholas Terrace, New York, NY, 10031, USA.
Liao W; New York Genome Center, New York, NY, 10013, USA.
Casaccia P; Neuroscience Initiative at the Advanced Science Research Center of the Graduate Center of the City University of New York, 85 St. Nicholas Terrace, New York, NY, 10031, USA. .; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Graduate Program in Biochemistry and in Biology, The Graduate Center of The City University of New York, 365 5th Avenue, New York, NY, 10016, USA. .
Źródło:
Neurochemical research [Neurochem Res] 2020 Mar; Vol. 45 (3), pp. 606-619. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press
MeSH Terms:
Lamin Type B/*genetics
Lamin Type B/*metabolism
Oligodendrocyte Precursor Cells/*physiology
Animals ; Cell Differentiation/physiology ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Gene Expression Profiling ; Mice ; Mice, Inbred C57BL ; Neurogenesis/physiology ; Nuclear Lamina/genetics ; Nuclear Lamina/metabolism ; Oligodendrocyte Precursor Cells/cytology ; Oligodendrocyte Precursor Cells/metabolism
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Grant Information:
R35 NS111604 United States NS NINDS NIH HHS
Contributed Indexing:
Keywords: Brain; Leukodystrophy; Myelin; Nuclear lamina
Substance Nomenclature:
0 (Lamin Type B)
Entry Date(s):
Date Created: 20200206 Date Completed: 20201221 Latest Revision: 20231213
Update Code:
20240105
PubMed Central ID:
PMC7060805
DOI:
10.1007/s11064-019-02941-y
PMID:
32020491
Czasopismo naukowe
Differentiation of oligodendrocytes (OL) from progenitor cells (OPC) is the result of a unique program of gene expression, which is further regulated by the formation of topological domains of association with the nuclear lamina. In this study, we show that cultured OPC were characterized by progressively declining levels of endogenous Lamin B1 (LMNB1) during differentiation into OL. We then identify the genes dynamically associated to the nuclear lamina component LMNB1 during this transition, using a well established technique called DamID, which is based on the ability of a bacterially-derived deoxyadenosine methylase (Dam), to modify genomic regions in close proximity. We expressed a fusion protein containing Dam and LMNB1 in OPC (OPC LMNB1-Dam ) and either kept them proliferating or differentiated them into OL (OL LMNB1-Dam ) and identified genes that were dynamically associated to LMNB1 with differentiation. Importantly, we identified Lss, the gene encoding for lanosterol synthase, a key enzyme in cholesterol synthesis, as associated to the nuclear lamina in OL LMNB1-Dam . This finding could at least in part explain the lipid dysregulation previously reported for mouse models of ADLD characterized by persistent LMNB1 expression in oligodendrocytes.

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