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Tytuł pozycji:

Derivation of cancer no significant risk levels and screening safety assessment for 2-nitropropane in spray products.

Tytuł:
Derivation of cancer no significant risk levels and screening safety assessment for 2-nitropropane in spray products.
Autorzy:
Gadagbui B; Toxicology Excellence for Risk Assessment (TERA), Cincinnati, Ohio.
Moore J; ANGUS Chemical Company, Buffalo Grove, Illinois.
Parker A; University of Cincinnati, Cincinnati, Ohio.
McCready D; EnviroCalc Consulting, South Charleston, West Virginia.
Monnot AD; Cardno ChemRisk, San Francisco, California.
Garnick L; Cardno ChemRisk, San Francisco, California.
Vincent M; Cardno ChemRisk, Cincinnati, Ohio.
Spencer P; ANGUS Chemical Company, Buffalo Grove, Illinois.
Maier A; Cardno ChemRisk, Cincinnati, Ohio.
Źródło:
Journal of applied toxicology : JAT [J Appl Toxicol] 2020 May; Vol. 40 (5), pp. 691-705. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
Język:
English
Imprint Name(s):
Publication: : Chichester : John Wiley And Sons
Original Publication: [Philadelphia, Pa. : Heyden & Son, c1981-
MeSH Terms:
Nitroparaffins/*toxicity
Propane/*analogs & derivatives
Solvents/*toxicity
Administration, Inhalation ; Administration, Oral ; Animals ; Humans ; Male ; Nasal Sprays ; Nitroparaffins/administration & dosage ; Oral Sprays ; Propane/administration & dosage ; Propane/toxicity ; Rats, Sprague-Dawley ; Risk Assessment ; Solvents/administration & dosage ; Toxicokinetics
References:
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Substance Nomenclature:
0 (Nasal Sprays)
0 (Nitroparaffins)
0 (Oral Sprays)
0 (Solvents)
GKV234L2QH (2-nitropropane)
T75W9911L6 (Propane)
Entry Date(s):
Date Created: 20200208 Date Completed: 20210712 Latest Revision: 20210712
Update Code:
20240105
DOI:
10.1002/jat.3937
PMID:
32030785
Czasopismo naukowe
Two proposition 65 no-significant-risk level (NSRL)-type values were derived for 2-nitropropane (2-NP), in the absence of a Californian published NSRL. In addition, a safety assessment was performed based on estimated typical consumer inhalation and dermal exposure to 2-NP during indoor application of paint from a spray can containing the solvent 1-nitropropane. For the NSRL derivation, benchmark dose (BMD) modeling was performed using hepatocellular carcinoma incidence data from 2-NP single exposure inhalation studies in Sprague-Dawley rats. Several BMD models provided an acceptable fit for the male rat hepatocellular carcinoma incidence data (gamma, log-probit, log-logistic and multistage); therefore, the mean of the BMD lower limits from each model were used as the point of departure to derive the inhalation cancer potency. The oral human cancer potency was derived from the inhalation human cancer potency based on the ratio of the uptake factors for inhalation vs. oral routes. The derived inhalation and oral NSRLs are 67 μg/day and 32 μg/day, respectively. For the inhalation and dermal exposure assessment, three key factors were analyzed: the 2-NP residual concentration in the spray paint product, the mass of spray paint used and the frequency of use. Based on the screening exposure assessment, potential consumer inhalation and dermal exposure to 2-NP from indoor application of paint from a spray can does not exceed our proposed NSRLs, and a warning label is therefore not required for spray can products containing the solvent 1-nitropropane where 2-NP is a minor contaminant.
(© 2020 John Wiley & Sons, Ltd.)

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