Differential Expression Hallmarks of Interneurons in Different Types of Focal Cortical Dysplasia.

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Tytuł:: Differential Expression Hallmarks of Interneurons in Different Types of Focal Cortical Dysplasia.
Autorzy:: Liang C; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Zhang CQ; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Chen X; Department of Neurosurgery, General Hospital of Western Theater Command, No.270 Rongdu Road, Jinniu District, Chengdu, Sichuan, 610083, People's Republic of China.
Wang LK; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Yue J; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
An N; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Zhang L; Department of Histology and Embryology, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Liu SY; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China.
Yang H; Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People's Republic of China. .; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China. .
Źródło:: Journal of molecular neuroscience : MN [J Mol Neurosci] 2020 May; Vol. 70 (5), pp. 796-805. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: Totowa, NJ : Humana Press
Original Publication: Boston : Birkhäuser [i.e. Cambridge, MA : Birkhäuser Boston, c1989-
MeSH Terms:: Drug Resistant Epilepsy/*pathology
Interneurons/*metabolism
Malformations of Cortical Development/*pathology
Adolescent ; Adult ; Cerebral Cortex/cytology ; Cerebral Cortex/pathology ; Child ; Child, Preschool ; Drug Resistant Epilepsy/metabolism ; Female ; Humans ; Infant ; Interneurons/classification ; Male ; Malformations of Cortical Development/metabolism ; Parvalbumins/genetics ; Parvalbumins/metabolism ; Somatostatin/genetics ; Somatostatin/metabolism ; Vasoactive Intestinal Peptide/genetics ; Vasoactive Intestinal Peptide/metabolism
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Grant Information:: 81471321 National Natural Science Foundation of China; 81701283 National Natural Science Foundation of China; 81771394 National Natural Science Foundation of China
Contributed Indexing:: Keywords: Development; Focal cortical dysplasia; Pediatric epilepsy; Vasoactive intestinal peptide interneurons
Substance Nomenclature:: 0 (Parvalbumins)
37221-79-7 (Vasoactive Intestinal Peptide)
51110-01-1 (Somatostatin)
Entry Date(s):: Date Created: 20200210 Date Completed: 20210104 Latest Revision: 20210104
Update Code:: 20240105
DOI:: 10.1007/s12031-020-01492-0
PMID:: 32036579
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Focal cortical dysplasia (FCD) is the main cause of medically intractable pediatric epilepsy. Previous studies have suggested that alteration of cortical interneurons and abnormal cytoarchitecture have been linked to initiation and development for seizure. However, whether each individual subpopulation of cortical interneurons is linked to distinct FCD subtypes remains largely unknown. Here, we retrospectively analyzed both control samples and epileptic specimens pathologically diagnosed with FCD types Ia, IIa, or IIb. We quantified three major interneuron (IN) subpopulations, including parvalbumin (PV)-, somatostatin (Sst)-, and vasoactive intestinal peptide (Vip)-positive INs across all the subgroups. Additionally, we calculated the ratio of the subpopulations of INs to the major INs (mINs) by defining the total number of the PV-, Sst-, and Vip-INs as mINs. Compared with the control, the density of the PV-INs in FCD type IIb was significantly lower, and the ratio of PV/mINs was lower in the superficial part of the cortex of the FCD type Ia and IIb groups. Interestingly, we found a significant increase in the ratio of Vip/mINs only in FCD type IIb. Overall, these results suggest that in addition to a reduction in PV-INs, the increase in Vip/mINs may be related to the initiation of epilepsy in FCD type IIb. Furthermore, the increase in Vip/mINs in FCD type IIb may, from the IN development perspective, indicate that FCD type IIb forms during earlier stages of pregnancy than FCD type Ia.

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