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Tytuł:
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Effect of vasopressin as a local anesthetic in mice.
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Autorzy:
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Katagiri K; Department of Dental Anesthesiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1-9-20 Fujimi Chiyoda-ku, Tokyo, 102-8159, Japan. .
Hashimoto S; School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan.
Sunda K; Department of Dental Anesthesiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1-9-20 Fujimi Chiyoda-ku, Tokyo, 102-8159, Japan.
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Źródło:
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Odontology [Odontology] 2020 Oct; Vol. 108 (4), pp. 626-635. Date of Electronic Publication: 2020 Feb 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Tokyo : Springer-Verlag Tokyo, c2001-
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MeSH Terms:
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Anesthetics, Local*
Mepivacaine*
Anesthesia, Local ; Animals ; Male ; Mice ; Mice, Inbred ICR ; Vasopressins
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Contributed Indexing:
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Keywords: Blood vessel; Epinephrine; Mepivacaine; Vasoconstriction; Vasopressin
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Substance Nomenclature:
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0 (Anesthetics, Local)
11000-17-2 (Vasopressins)
B6E06QE59J (Mepivacaine)
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Entry Date(s):
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Date Created: 20200211 Date Completed: 20200821 Latest Revision: 20200821
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Update Code:
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20240105
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DOI:
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10.1007/s10266-020-00491-2
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PMID:
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32040654
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We sought to elucidate how the local administration of mepivacaine hydrochloride and vasopressin via the tail affects the peripheral blood flow volume, tissue dynamics, and mepivacaine's anesthetic effect in mice. Two-hundred and twenty-six male ICR mice were used in this study. Blood flow was measured after administering mepivacaine alone or mepivacaine with either 0.03, 0.3, or 3.0 U/mL vasopressin or 10 µg/mL epinephrine via the tail tissue. The tail tissue and blood dynamics were measured using 3 H-labeled mepivacaine hydrochloride with vasopressin or epinephrine. The compound nerve action potential (CNAP) was measured to clarify the anesthetic effect after administering mepivacaine with 0.3 U/mL vasopressin. The statistical methods employed were Steel-Dwass test, Mann-Whitney U test, Dunnett's test, and Tukey test. P < 0.05 indicated statistical significance. The results revealed that the local administration of ≥ 0.03 U/mL vasopressin reduced local blood flow and prolonged 3 H-M localization in the tail tissue in a concentration-dependent manner. Addition of 0.3 U/mL vasopressin enhanced and prolonged the anesthetic effect of mepivacaine. The findings suggest that adding vasopressin to a local anesthetic regimen may be effective, and thus it could be applied as a vasoconstrictor.