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Tytuł pozycji:

Effect of vasopressin as a local anesthetic in mice.

Tytuł:
Effect of vasopressin as a local anesthetic in mice.
Autorzy:
Katagiri K; Department of Dental Anesthesiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1-9-20 Fujimi Chiyoda-ku, Tokyo, 102-8159, Japan. .
Hashimoto S; School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan.
Sunda K; Department of Dental Anesthesiology, School of Life Dentistry at Tokyo, Nippon Dental University, 1-9-20 Fujimi Chiyoda-ku, Tokyo, 102-8159, Japan.
Źródło:
Odontology [Odontology] 2020 Oct; Vol. 108 (4), pp. 626-635. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Tokyo : Springer-Verlag Tokyo, c2001-
MeSH Terms:
Anesthetics, Local*
Mepivacaine*
Anesthesia, Local ; Animals ; Male ; Mice ; Mice, Inbred ICR ; Vasopressins
Contributed Indexing:
Keywords: Blood vessel; Epinephrine; Mepivacaine; Vasoconstriction; Vasopressin
Substance Nomenclature:
0 (Anesthetics, Local)
11000-17-2 (Vasopressins)
B6E06QE59J (Mepivacaine)
Entry Date(s):
Date Created: 20200211 Date Completed: 20200821 Latest Revision: 20200821
Update Code:
20240105
DOI:
10.1007/s10266-020-00491-2
PMID:
32040654
Czasopismo naukowe
We sought to elucidate how the local administration of mepivacaine hydrochloride and vasopressin via the tail affects the peripheral blood flow volume, tissue dynamics, and mepivacaine's anesthetic effect in mice. Two-hundred and twenty-six male ICR mice were used in this study. Blood flow was measured after administering mepivacaine alone or mepivacaine with either 0.03, 0.3, or 3.0 U/mL vasopressin or 10 µg/mL epinephrine via the tail tissue. The tail tissue and blood dynamics were measured using 3 H-labeled mepivacaine hydrochloride with vasopressin or epinephrine. The compound nerve action potential (CNAP) was measured to clarify the anesthetic effect after administering mepivacaine with 0.3 U/mL vasopressin. The statistical methods employed were Steel-Dwass test, Mann-Whitney U test, Dunnett's test, and Tukey test. P < 0.05 indicated statistical significance. The results revealed that the local administration of ≥ 0.03 U/mL vasopressin reduced local blood flow and prolonged 3 H-M localization in the tail tissue in a concentration-dependent manner. Addition of 0.3 U/mL vasopressin enhanced and prolonged the anesthetic effect of mepivacaine. The findings suggest that adding vasopressin to a local anesthetic regimen may be effective, and thus it could be applied as a vasoconstrictor.

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