-
Tytuł:
-
Plasma inorganic pyrophosphate and alkaline phosphatase in patients with pseudoxanthoma elasticum.
-
Autorzy:
-
Sánchez-Tévar AM; Lipid and Arteriosclerosis Laboratory, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Málaga, Málaga, Spain.
García-Fernández M; Department of Physiology, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.
Murcia-Casas B; Internal Medicine Unit, Hospital Virgen de la Victoria, Málaga, Spain.
Rioja-Villodres J; Lipid and Arteriosclerosis Laboratory, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Málaga, Málaga, Spain.; Department of Medicine and Dermatology, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.
Carrillo JL; Internal Medicine Unit, Hospital Virgen de la Victoria, Málaga, Spain.
Camacho M; Obstetric and Gynecology Department, Hospital Virgen de la Victoria, Málaga, Spain.
Van Gils M; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Sánchez-Chaparro MA; Lipid and Arteriosclerosis Laboratory, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Málaga, Málaga, Spain.; Internal Medicine Unit, Hospital Virgen de la Victoria, Málaga, Spain.; Department of Medicine and Dermatology, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.
Vanakker O; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Valdivielso P; Lipid and Arteriosclerosis Laboratory, Centro de Investigaciones Médico-Sanitarias (CIMES), University of Málaga, Málaga, Spain.; Internal Medicine Unit, Hospital Virgen de la Victoria, Málaga, Spain.; Department of Medicine and Dermatology, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.
-
Źródło:
-
Annals of translational medicine [Ann Transl Med] 2019 Dec; Vol. 7 (24), pp. 798.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: [Hong Kong] : AME Publishing Company
-
References:
-
J Invest Dermatol. 2014 Jul;134(7):1855-1861. (PMID: 24670382)
Curr Osteoporos Rep. 2017 Aug;15(4):255-270. (PMID: 28585220)
Front Cardiovasc Med. 2019 Jan 18;5:196. (PMID: 30713844)
Sci Signal. 2016 Dec 13;9(458):ra121. (PMID: 27965423)
Sci Transl Med. 2017 Jun 7;9(393):. (PMID: 28592560)
Am J Med Genet A. 2010 Apr;152A(4):1049-58. (PMID: 20358627)
Anal Biochem. 2004 Apr 15;327(2):209-14. (PMID: 15051537)
Kidney Int. 2008 May;73(9):1024-30. (PMID: 18288101)
Cell Signal. 2019 Mar;55:119-129. (PMID: 30615970)
Circulation. 2008 Jun 3;117(22):2938-48. (PMID: 18519861)
J Invest Dermatol. 2019 Feb;139(2):360-368. (PMID: 30130617)
Atherosclerosis. 2019 Jan;280:75-84. (PMID: 30476723)
Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. (PMID: 29174347)
Nat Rev Nephrol. 2017 Jul;13(7):429-442. (PMID: 28502983)
Clin Lab. 2012;58(11-12):1129-34. (PMID: 23289181)
EMBO Mol Med. 2017 Nov;9(11):1463-1470. (PMID: 28701330)
Ann Clin Biochem. 2007 Nov;44(Pt 6):544-8. (PMID: 17961309)
J Invest Dermatol. 2013 Apr;133(4):946-54. (PMID: 23223140)
Biochim Biophys Acta. 2013 Dec;1832(12):2044-56. (PMID: 23899605)
J Clin Pathol. 1992 Jan;45(1):68-71. (PMID: 1740521)
J Dermatol Sci. 2014 Apr;74(1):72-80. (PMID: 24461675)
J Invest Dermatol. 2017 Nov;137(11):2336-2343. (PMID: 28652107)
J Invest Dermatol. 2018 Aug;138(8):1862-1870. (PMID: 29501384)
Anal Biochem. 2001 Jun 1;293(1):67-70. (PMID: 11373080)
Thromb Res. 1981 Jul 1-15;23(1-2):69-77. (PMID: 7302923)
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1985-9. (PMID: 24969777)
Curr Opin Pharmacol. 2016 Jun;28:57-68. (PMID: 27061894)
Orphanet J Rare Dis. 2014 Apr 29;9:66. (PMID: 24775865)
J Med Genet. 2007 Oct;44(10):621-8. (PMID: 17617515)
-
Contributed Indexing:
-
Keywords: CD73; ENPP1; Pseudoxanthoma elasticum (PXE); alkaline phosphatase (AP); calcification; inorganic pyrophosphate (PPi); non-specific tissue alkaline phosphatase (TNAP)
-
Entry Date(s):
-
Date Created: 20200212 Latest Revision: 20220412
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC6989879
-
DOI:
-
10.21037/atm.2019.12.73
-
PMID:
-
32042814
-
Background: Inorganic pyrophosphate (PPi) plays a major role inhibiting dystrophic calcification. The aim was to analyze levels of PPi in patients having pseudoxanthoma elasticum (PXE), and controls as well as the enzymes who regulate the PPi plasma concentration.
Methods: We collected fasting blood samples from PXE patients and age- and sex-matched controls in ethylenediamine tetraacetic acid (EDTA) and citrate-theophylline-adenosine-dipyridamole (CTAD) containing tubes. We measured PPi, ENPP1 mass and activity, alkaline phosphatase (AP) and tissue non-specific alkaline phosphatase (TNAP), CD73 and Human Platelet Factor-4 (CXCL4).
Results: PPi in EDTA and CTAD samples were lower in PXE subjects than in controls (1.11±0.26 vs. 1.43±0.41 µM/L and 0.35±0.15 vs. 0.61±0.18 µM/L respectively, P<0.05). TNAP and liver TNAP activities were also higher in PXE than in controls (80.3±27.0 vs. 63.3±16.4 UI/L and 25.6±14.9 vs. 12.9±9.2 UI/L respectively, P<0.05). ENPP1 mass and activity as well as CD73 were almost identical. There was a weak but significant inverse correlation between TNAP activity and PPi levels (Pearson correlation -0.379, P<0.05) in both groups.
Conclusions: High TNAP activity seems to contribute to low plasma levels of PPi in subjects with PXE, reinforcing the idea that pharmacological reduction of TNAP activity may help to reduce dystrophic calcification in PXE patients.
Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
(2019 Annals of Translational Medicine. All rights reserved.)
