Cardio-metabolic risk factors among young infertile women: a systematic review and meta-analysis.

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Abstrakt

Tytuł:: Cardio-metabolic risk factors among young infertile women: a systematic review and meta-analysis.
Autorzy:: Mulder CL; Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.; Centre for Reproductive Medicine, Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, University of Amsterdam, AZ Amsterdam, the Netherlands.
Lassi ZS; Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Grieger JA; Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Ali A; Basil Hetzel Institute, The University of Adelaide, Adelaide, SA, Australia.
Jankovic-Karasoulos T; Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Roberts CT; Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Andraweera PH; Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Źródło:: BJOG : an international journal of obstetrics and gynaecology [BJOG] 2020 Jul; Vol. 127 (8), pp. 930-939. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji:: Journal Article; Meta-Analysis; Systematic Review
Język:: English
Imprint Name(s):: Publication: : Oxford : Wiley-Blackwell
Original Publication: Oxford [England] : Blackwell Science, [2000]-
MeSH Terms:: Cardiovascular Diseases/*physiopathology
Disease Susceptibility/*physiopathology
Hyperandrogenism/*physiopathology
Infertility, Female/*physiopathology
Metabolic Syndrome/*physiopathology
Polycystic Ovary Syndrome/*physiopathology
Adult ; Body Mass Index ; Cardiovascular Diseases/blood ; Cholesterol, LDL/blood ; Disease Susceptibility/blood ; Female ; Humans ; Hyperandrogenism/blood ; Hyperandrogenism/complications ; Infertility, Female/blood ; Infertility, Female/etiology ; Insulin Resistance/physiology ; Metabolic Syndrome/blood ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/complications ; Risk Factors ; Triglycerides/blood
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Grant Information:: TMB18/345 International Royal Netherlands Academy of Arts and Sciences Ter Meulen Grant; APP1090778 International NHMRC Peter Doherty BioMedical Postdoctoral Fellowship; APP1141382 International NHMRC Public Health Postdoctoral Fellowship; International Lloyd Cox Professorial Research Fellow at the University of Adelaide
Contributed Indexing:: Keywords: Cardio-metabolic risk factors; cardiovascular disease; female infertility
Substance Nomenclature:: 0 (Cholesterol, LDL)
0 (Triglycerides)
Entry Date(s):: Date Created: 20200213 Date Completed: 20200630 Latest Revision: 20200630
Update Code:: 20240105
DOI:: 10.1111/1471-0528.16171
PMID:: 32048421
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Background: There is currently no concise systematic review or meta-analysis addressing cardio-metabolic risk factors in women experiencing infertility.
Objectives: To determine whether infertile women have higher levels of cardiovascular risk factors compared with fertile women.
Search Strategy: We performed a systematic literature search using PubMed, Embase and CINAHL, Scopus and additional manual and bibliographic searches for relevant articles (end search date 6 November 2019).
Selection Criteria: We selected studies that compared cardio-metabolic risk factors in fertile and infertile women of reproductive age.
Data Collection and Analysis: At least two authors independently screened potentially eligible studies.
Main Results: There was an increased presence of several cardio-metabolic risk factors in infertile women compared with fertile women. Infertile women had statistically significant higher body mass index (BMI), increased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) compared with fertile women. Fasting glucose, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR) and mean arterial pressure were not found to be different between fertile and infertile women. A subgroup analysis revealed that TC, fasting glucose and fasting insulin were increased, and high-density lipoprotein was decreased only in women with polycystic ovarian syndrome compared with fertile women, whereas BMI, TG and LDL-C were statistically significantly increased in women with any indication of infertility compared with fertile women.
Conclusions: Infertile women have a higher level of cardio-metabolic risk factors compared with fertile women. This finding has clinical implications for infertile women in general, and those attempting to conceive through medically assisted reproduction.
Tweetable Abstract: Infertile women appear to have a higher level of cardio-metabolic risk factors compared with fertile women.
(© 2020 Royal College of Obstetricians and Gynaecologists.)

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