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Tytuł:
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Nutritional risk screening score is associated with omission of adjuvant chemotherapy for stage III colon cancer.
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Autorzy:
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Lee SY; Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.
Yeom SS; Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.
Kim CH; Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea.
Kim HR; Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, South Korea. Electronic address: .
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Źródło:
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American journal of surgery [Am J Surg] 2020 Oct; Vol. 220 (4), pp. 993-998. Date of Electronic Publication: 2020 Feb 07.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Belle Mead, NJ : Excerpta Medica
Original Publication: New York.
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MeSH Terms:
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Neoplasm Staging*
Nutrition Assessment*
Colonic Neoplasms/*therapy
Early Detection of Cancer/*methods
Aged ; Chemotherapy, Adjuvant ; Colonic Neoplasms/diagnosis ; Female ; Follow-Up Studies ; Humans ; Male ; Prognosis ; Retrospective Studies
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Contributed Indexing:
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Keywords: Chemotherapy; Colon cancer; Nutrition; Survival
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Entry Date(s):
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Date Created: 20200215 Date Completed: 20201123 Latest Revision: 20201123
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Update Code:
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20240105
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DOI:
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10.1016/j.amjsurg.2020.02.015
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PMID:
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32057413
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Background: This study aimed to evaluate the association between nutritional risk screening (NRS) score and administration of adjuvant chemotherapy for stage III colon cancer.
Methods: A total of 404 patients with stage III colon cancer who underwent curative resection between January 2012 and December 2015 were included. Patients with a preoperative high nutritional risk score (NRS ≥4) were compared with those with an NRS <4. Predictive factors for omission of adjuvant chemotherapy, and prognostic factors for overall survival (OS) were analyzed.
Results: Eighty (19.8%) patients had a high nutritional risk (NRS ≥4). An NRS score ≥4 was associated with higher risk of omission of adjuvant chemotherapy (26.3% vs. 13.6%, p = 0.006), which was significant after adjusting for covariables (odds ratio = 1.862, p = 0.047). Multivariable survival analysis showed that omission of adjuvant chemotherapy was an independent poor prognostic factor for OS (hazard ratio = 4.060, p < 0.001).
Conclusions: An NRS score ≥4 was associated with omission of adjuvant chemotherapy in stage III colon cancer, which resulted in poor OS.
Competing Interests: Declaration of competing interest The abstract of this article was presented at the Digestive Disease Week in San Diego, CA, USA on May 19, 2019. The authors declare no conflicts of interest.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
