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Tytuł pozycji:

CT-Derived Fractional Flow Reserve (FFR CT ): From Gatekeeping to Roadmapping.

Tytuł :
CT-Derived Fractional Flow Reserve (FFR CT ): From Gatekeeping to Roadmapping.
Autorzy :
Huang AL; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Maggiore PL; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Brown RA; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Turaga M; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Reid AB; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Merkur J; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Blanke P; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Leipsic JA; Department of Medical Imaging, St Paul's Hospital, Vancouver, BC, Canada.
Pokaż więcej
Źródło :
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes [Can Assoc Radiol J] 2020 May; Vol. 71 (2), pp. 201-207. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article; Review
Język :
English
Imprint Name(s) :
Publication: 2020- : Thousand Oaks, CA : SAGE Publications
Original Publication: [Montreal, Quebec : Medicöpea International Inc., 1986-
MeSH Terms :
Computed Tomography Angiography*
Fractional Flow Reserve, Myocardial*
Coronary Artery Disease/*diagnostic imaging
Clinical Decision-Making ; Coronary Angiography ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/surgery ; Humans ; Hydrodynamics ; Myocardial Revascularization ; Sensitivity and Specificity
Contributed Indexing :
Keywords: CAD; CCTA; CT; FFRCT; atherosclerosis; cardiac
Entry Date(s) :
Date Created: 20200218 Date Completed: 20200413 Latest Revision: 20200413
Update Code :
20201023
DOI :
10.1177/0846537119893752
PMID :
32063007
Czasopismo naukowe
Coronary computed tomography angiography (CCTA) has emerged as the preferred modality in the diagnosis of coronary artery disease, but it is limited by modest specificity. By applying principles of computational fluid dynamics, flow fraction reserve, a measure of lesion-specific ischemia that is used to guide revascularization, can be noninvasively derived from CCTA, the so-called computed tomography-derived flow fractional reserve (FFR CT ). The accuracy of FFR CT in discriminating ischemia has been extensively validated, and it has been shown to improve the specificity of CCTA. Compared to other stress myocardial perfusion imaging, FFR CT has superior or comparable accuracy. Clinical studies have provided strong evidence that FFR CT has significant prognostic implications and informs clinical decisions for revascularization, serving as a gatekeeper to invasive coronary angiography. In addition, FFR CT-based tools can be used to simulate the physiological consequences of different revascularization strategies, thus providing the roadmap to achieve complete revascularization. Although challenges remain, ongoing research and randomized controlled trials are expected to address current limitations and better define its role in clinical practice.

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