X-ray computed tomography in life sciences.

Tytuł:: X-ray computed tomography in life sciences.
Autorzy:: Rawson SD; The Henry Royce Institute and School of Materials, The University of Manchester, Manchester, M13 9PL, UK.
Maksimcuka J; The Henry Royce Institute and School of Materials, The University of Manchester, Manchester, M13 9PL, UK.
Withers PJ; The Henry Royce Institute and School of Materials, The University of Manchester, Manchester, M13 9PL, UK.
Cartmell SH; The Henry Royce Institute and School of Materials, The University of Manchester, Manchester, M13 9PL, UK. .
Źródło:: BMC biology [BMC Biol] 2020 Feb 27; Vol. 18 (1), pp. 21. Date of Electronic Publication: 2020 Feb 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
Język:: English
Imprint Name(s):: Original Publication: [London] : BioMed Central, c2003-
MeSH Terms:: Biological Science Disciplines/*methods
Tomography, X-Ray Computed/*methods
Animals ; Biological Science Disciplines/instrumentation ; Humans ; Mice ; Rats
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Grant Information:: EP/L014904/1 United Kingdom MRC_ Medical Research Council
Contributed Indexing:: Keywords: 3D histology; 3D imaging; Correlative microscopy; Elemental mapping; Lightsheet; Phase contrast; Quantitative tomography; Time-lapse tomography; Water window; X-ray computed tomography
Entry Date(s):: Date Created: 20200228 Date Completed: 20200929 Latest Revision: 20240328
Update Code:: 20240329
PubMed Central ID:: PMC7045626
DOI:: 10.1186/s12915-020-0753-2
PMID:: 32103752
: Czasopismo naukowe

Pełny tekst

Recent developments within micro-computed tomography (μCT) imaging have combined to extend our capacity to image tissue in three (3D) and four (4D) dimensions at micron and sub-micron spatial resolutions, opening the way for virtual histology, live cell imaging, subcellular imaging and correlative microscopy. Pivotal to this has been the development of methods to extend the contrast achievable for soft tissue. Herein, we review the new capabilities within the field of life sciences imaging, and consider how future developments in this field could further benefit the life sciences community.

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